| 摘要: |
| [目的]研究不同剂量黄芪注射液对急性心衰大鼠的作用。[方法]用戊巴比妥钠造成大鼠急性心衰的方法,观察不同剂量的黄芪注射液对衰竭心脏大鼠血流动力学各指标的变化。[结果]黄芪注射液各剂量组与空白对照组比较,高、中两个剂量黄芪注射液能明显增强心肌收缩力、使心率加快、血压升高 (P<0.05~0.01);小剂量组对心衰大鼠上述各血流动力学指标无明显影响 (P>0.05),[结论]黄芪注射液高、中两个剂量组有抗心力衰竭的作用。 |
| 关键词: 黄芪注射液 急性心力衰竭 血流动力学 实验研究 |
| DOI：10.11656/j.issn.1672-1519.2003.06.27 |
| 分类号: |
| 基金项目:邯郸市科委基金资助项目 (20144) |
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| Experimental research about the influence of Huangqi Injection on hemodynamics in rats with acute heart failure |
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LI Shu-rui,HAO Jian-feng,WANG Yi
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Hebei Handan Center Hospital, Handan 056001, China
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| Abstract: |
| [Objective] To investigate the influence of Huangqi Injection in different dosages in rats with acute heart failure (AHF).[Methods] The AHF models were reproduced in rats by pentobarbital sodium. The changes of hemodynamics were observed in rats with acute heart failure treated with Huangqi Injection in different dosages.[Results] Large and middle dosage of Huangqi Injection can obviously enhance cardiac contractility, increase heart rate and rise blood pressure (P<0.05~0.01) with no significant influence on above-mentioned indexes of hemodynamics in rats with acute heart failure in Huangqi Injection group of small dosage (P>0.05).[Conclusion] Large and middle dosage of Huangqi Injectioin had effect against heart failure. |
| Key words: Huangqi Injection acute heart failure hemodynamics experimental research |
