贝甲汤(散)治疗痤疮88例

关键词:  痤疮  中医药疗法  贝甲汤

摘要:

患者均为2001-2003年门诊病人,其中男48例,女40例,年龄14～35岁。病程最短者两个月,最长者7a。88例中轻度(Ⅰ级)13例,中度(Ⅱ级)21例,中度(Ⅲ级)28例,重度(Ⅳ级)26例。并发皮脂溢出症26例,并发脂溢性皮炎6例,伴便秘33例,形体偏胖者47例。

Abstract:

[Objective] To explore whether the mechanism of the cellular protection of salvisnolic acid B (Sal B) preconditioning is relevant with the synthesis of the heat shock protein 70 (HSP70). [Methods] Technique of RT-PCR was adopted,and the impact of Sal B preconditioning on the expression of heat shock protein 70 (HSP70) mRNA in cardiac microvascular endothelial cells (CMEC) injured by hypoxia and reoxygenation was observed. [Results] HSP70 produced less expression in normal CMEC and its expression was increased significantly by hypoxia stimulating. Sal B preconditioning enhanced the expression of HSP70 mRNA and the effect was obviously superior to that of hypoxic preconditioning (HPC). During the delayed preconditioning protection, Sal B also could increase the HSP70 mRNA expression and enhance the effect of HPC. [Conclusion] Sal B preconditioning produces a protective effect on cells by inducing the expression of HSP70.