针刺镇痛与中枢神经系统神经元内外游离钙离子浓度的关系

Relationship between Acupuncture Analgesia and Concentration of Free Calcium inside and outside the Neuron ofCentral Nervous System

关键词:  针刺镇痛  中枢神经系统  神经元  游离钙离子

Key words:  acupuncture analgesia  central nervous system  neuron  free calcium

摘要:

[目的]探讨针刺镇痛与中枢神经系统神经元内外游离钙离子浓度的关系。[方法]首先通过大鼠痛阈的变化,观察外源性升高中脑中央灰质(PAG)部位游离Ca²⁺浓度对针刺效应的影响。其次,通过实验性疼痛大鼠模型,观察疼痛刺激及针刺镇痛对PAG细胞内游离Ca²⁺浓度的影响。[结果]外源性升高PAG部位游离Ca²⁺浓度后,针刺提高大鼠痛阈的效应受到抑制。疼痛刺激使大鼠PAG部位神经元内游离Ca²⁺浓度显著升高,针刺镇痛则可使其明显降低。[结论]中枢神经系统神经元内游离Ca²⁺可能是伤害性刺激信息和针刺信息相互作用的物质基础之一。

Abstract:

[Objective] To explore the relationship between acupuncture analgesia and the concentration of free calcium inside and outside the neuron of central nervous system. [Methods] First,observe the influence of raising the concentration of free calcium outside the neuron in periaqueductal gray PAG on acupuncture effect by the change of rat’s pain threshold.Second,observe the influence of painful stress and acupuncture analgesia on the concentration of free calcium inside the neuron([Ca²⁺]i) of PAG in rat with experimental pain. [Results] The acupuncture effect that raising rat’s pain threshold was restrained by raising the concentration of free calcium outside the neuron in PAG.Affected by pain,the concentration of free calcium inside the neuron in PAG ascended.But it can be descended by acupuncture analgesia. [Conclusion] In central nervous system,the free calcium inside the neuron may be a material basis through which injury messages and acupuncture messages interact each other.