| 摘要: |
| [目的]探讨丹酚酸B对心肌细胞(CM)抗缺氧损伤保护作用的途径。[方法]基于缺氧预适应的保护机制,通过缺氧/复氧的CM损伤模型,利用蛋白激酶C(PKC)抑制剂这一工具药,观察丹酚酸B对心肌细胞预适应在PKC途径中的作用,探讨丹酚酸B对心肌细胞保护的机制。[结果]丹酚酸B预适应可产生预适应样的保护作用,并且能促进被抑制的缺氧预适应(HPC)效应重现。[结论]丹酚酸B预适应与HPC具有相类似的细胞保护效应,可增强心肌细胞对随后较长时间缺氧/复氧损伤的耐受性,其机制可能是通过激活蛋白激酶C通路实现的。 |
| 关键词: 丹酚酸B 预适应 心肌细胞 蛋白激酶C |
| DOI：10.11656/j.issn.1672-1519.2005.05.29 |
| 分类号: |
| 基金项目:天津市自然科学基金资助项目(013612711) |
|
| Protective Effect on Cardiac Muscle in the Transduction Pathway of Protein Kinase C by using Sal B Accommodation in Advanc |
|
DU Rong,ZHANG Meng,GUO Li-ping
|
|
Tianjin University of TCM, Tianjin 300193, China
|
| Abstract: |
| [Objective] To discuss on Sal B protective effect pathway on cardiac muscle cell against injury due to hypoxia. [Methods] To observe the Sal B effect on cardiac muscle in the pathway of protein kinase C PKC.To discuss on the mechanism of cell protection about Sal B.To establish the CM injury model due to hypoxia and oxygen.recovery by using PKC depressantia. [Result] The accommodation in advance of Sal B may produce the protective effect of pre.adapting sample.The Sal B can promote the effect recovery of hypoxia preconditioning HPC. [Conclusion] The accommodation in advance of Sal B and HPC had similarly cell protection effect.The Sal B may enhance the toleration of injury due to hypoxia and oxygen.recovery by activating protein kinase C pathway in the later time. |
| Key words: the accommodation in advance of Sal B cardiac muscle cell protein kinase C |
