中药联合用药治疗湿热阻络型类风湿关节炎疗效评价

Curative Effect of Combined Chinese Medicines on Rheumatoid Arthritis with Damp-heat Blocking Collaterals

关键词:  类风湿关节炎  湿热阻络型  中药  联合  疗效评价  不良反应

Key words:  rheumatoid arthritis  damp-heat blocking collaterals syndrome  traditional Chinese medicine  association  evaluation of curative effect  adverse effect

摘要:

[目的]根据治疗类风湿关节炎(RA)提倡早期扶正和活血化瘀两法的使用,对于湿热阻络型RA注重清热解毒法的运用,选取了3种有代表性的中药联合治疗湿热阻络型RA,观察药物的疗效和不良反应。[方法]将50例RA患者随机分为治疗组和对照组,治疗组口服雷公藤多苷片、痹祺胶囊和清痹片,对照组口服扶他林、甲氨喋呤和柳氮磺胺吡啶,用药期间监测安全性指标,并定期进行临床疗效评价。[结果]治疗组用药后4周起效,总有效率为56%与对照组80%相比,差异无显著性(P>0.05);12周和24周治疗组总有效率分别为84%、88%,对照组为88%、92%,两组总有效率差异无显著性(P>0.05)。治疗组和对照组不良反应发生率分别为12%、36%,差异有显著性(P<0.05)。[结论]中药联合用药治疗RA疗效与西药组相当,但不良反应发生率低。说明中药联合治疗RA是安全有效的。

Abstract:

[Objective] We advocate using both strengthening the body resistance early and activating blood circulation and removing stasis for treating rheumatoid arthritis(RA)with putting emphasis on clearing away heat-toxin in RA with damp-heat blocking collaterals and observe the curative effect and adverse effect.[Methods] Fifty patients with RA were randomly divided into treatment group and control group.The treatment group was administrated with tablet of polyglucoside of Radix Tripteryglli Wilfordii,Biqi capsule and Qingbi(clearing away arthralgia)tablet.The control group was administrated with voltaren,methopterin and sulphasalazine.The safety was observed during treatment and evaluate the clinical curative periodically.[Result] The treatment group began to be effective from the fourth week after treatment.The total effective rate of treatment group was 56% and that in control group was 80% with no obvious difference between them(P>0.05).The total effective rate of treatment group was 4% and 88% respectively in the twelfth and twenty-fourth week and that in control group was respectively 88% and 92% respectively.There wasn’t obvious difference between them(P>0.05).The rate of adverse effect rate in treatment group was 12% and that of control group was 36%.There was a significant difference between these groups(P<0.05).[Conclusion] The combined treating with traditional Chinese medicines has similar effect to Western medicine in treating RA with less adverse effects,suggesting that the treating is safe and effective.