| 摘要: |
| [目的]采用ED-NM-MO三联法对经基线等比增减设计的丹参、三七不同配比的药效学数据进行非线性拟合和多目标优化。[方法]对经基线等比增减设计的丹参、三七不同配比的药效学数据,以心肌缺血程度Σ-ST、心肌缺血程度(缺血区左室)等7个分别反映心肌缺血、心脏状态和血流动力学的指标作为待优化的药效目标,进行非线性拟合和多目标优化。[结果]分别得到针对7个药效指标和6个药效指标(不包含血清中心肌钙蛋白)的Pareto最优配比。[结论]ED-NM-MO三联法是一种适合复方特点的优化方法,可以应用于由多饮片多组分多成分复方药物的剂量配比优化。 |
| 关键词: ED-NM-MO三联法 丹参、三七配比 基线等比增减设计 非线性拟合 多目标优化 RBF神经网络 进化算法 PAES Pareto最优解集 直接选择法 归一化加权选择法 |
| DOI：10.11656/j.issn.1672-1519.2006.03.31 |
| 分类号: |
| 基金项目:国家重点基础发展规划项目资助(NO.G19990544) |
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| Multi-objective Optimization Research of The Ratio of Danshen and Sanchi with ED-NM-MO Trigeminy Method |
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WANG Rui1, SHANG Hong-cai2, WANG Yong-yan3
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1.Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, China;2.Tianjin University of TCM, Tianjin 300193, China;3.Chinese Academy of TCM, Beijing 100700, China
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| Abstract: |
| [Objective] To optimize the dosage and ratio of danshen(Rasix Salviae Milt orrgizae) and sanchi(Radix Notoginseng) by processing the experimental data with ED-NM-MO Method. [Methods] Aimed at pharmacodynamics indexes, the pharmacodynamic data of the ratio of danshen and sanchi based on baseline geometric proportion increasing and decreasing design were nonlinearity fitted and multi-objective optimized. [Results] Pareto optimal ratio for six and seven pharmacodynamics indexes was individually obtained. [Conclusions] ED-NM-MO Method is suited for the researching of the characters of Chinese medicine, and it can be used for the optimization of dosage and ratio of herb or component compound. |
| Key words: ED-NM-MO Method the ratio of danshen and sanchi baseline geometric proportion increasing and decreasing design nonlinear fitting multi-objective optimization RBF NN Evolutionary Program the Pareto Archived Evolution Strategy(PAES) Pareto optimal solution |
