正交法优选淫羊藿苷-羟丙基β-环糊精包合物的制备工艺

Optimizing Preparation Technique of Inclusion Compound of Icariin-hydroxypropyl-β-cylodextrin by Orthogonal Methods

关键词:  淫羊藿苷  羟丙基-β-环糊精  包合物  正交实验

Key words:  Icariin  Hydroxyproply-β-cyclodextrin  inclusion compound  Orthogonal test

摘要:

[目的]研究淫羊藿苷-羟丙基-β-环糊精包合物制备工艺。[方法]采用正交试验法优选淫羊藿苷-羟丙基-β-环糊精对淫羊藿苷的包合工艺。[结果]以包合物的溶解度为指标,筛选出最佳包合条件:羟丙基-β-环糊精浓度为40%,包合温度为40℃,搅拌时间为4h。[结论]经羟丙基-β-环糊精包合后,淫羊苷的溶解度由0.02g/L增加到4.46g/L。

Abstract:

[Objective] To investigate the preparation technique of the inclusion compound of Icariin-hydroxypropyl-β-cylodextrin(HP-β-CD).[Methods] The preparation technique of the inclusion procedure of icariin-hydroxypropyl-β-cylodextrin was optimized by orthogonal test methods.[Results] The Optimal reparative technique of the inclusion compound of Icariin-hydroxypropyl-β-cylodextrin was screened out using solubility as the index:the concentration of 40% HP-β-CD was 40%,the temperature of inclusion procedure was 40℃ and the stirring time 4 hours.[Conclusions] The solubility of Icariin was increased from 0.02 mg/ml to 4.46 mg/ml when it was included by HP-β-CD.