| 摘要: |
| [目的]研究冰片-羟丙基-β-环糊精包合物的制备方法及包合物的验证。[方法]采用冷冻干燥法制备冰片-羟丙基-β-环糊精包合物,并经薄层色谱、X线衍射、相溶解度曲线、核磁共振、扫描电镜等方法对包合物进行验证。[结果]冰片已和羟丙基-β-环糊精形成包合物。[结论]羟丙基-β-环糊精可以包合冰片,使冰片在水中溶解度提高。 |
| 关键词: 冰片 羟丙基-β-环糊精 包合物 |
| DOI：10.11656/j.issn.1672-1519.2007.02.30 |
| 分类号: |
| 基金项目:天津市科技发展计划项目课题(043180911)。 |
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| Study on the inclusion complex of borneol with hydroxypropyl-β-cyclodextrin |
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WANG Jing11, ZHANH Tie-jun22, LIAO Mao-liang2
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1.Tianjin University of TCM, Tianjin 300190, China;2.Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
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| Abstract: |
| [Objective] To study the preparation technology of the inclusion complex of the borneol-hydroxypropyl-β-cyclodextrin and identify the formation of inclusion complex. [Methods] The inclusion complex was prepared by freeze-drying technique. Its structure was proved by TLC, phase solubility diagram, X-ray diffraction, NMR, SEM. [Results] The results indicated that the inclusion complex of the borneol- hydroxypropyl-β-cyclodextrin was formed. [Conclusions] Hydroxypropyl-β-cyclodextrin is available to include the borneol. The solubility of borneol is increased in aqueous solution. |
| Key words: borneol hydroxypropyl-β-cyclodextrin inclusion complex phase solubility diagram, X-ray diffraction |
