中药治疗血管性痴呆的系统评价

Systemic evaluation in treating vascular dementia with TCM

关键词:  血管性痴呆  中药治疗  系统评价  荟萃分析

Key words:  vascular dementia  systemic evaluation  Mini-Mental State

摘要:

[目的]系统评价中药治疗血管性痴呆的有效性和安全性。[方法]电子检索及手工检索相关文献,采用Cochrane Reviewer’s Handbook4.2.2中的方法进行文献质量评价和资料分析。[结果]共纳入14个研究,进行Jadad评分。采用RevMan4.2进行荟萃(Meta)分析:中药可改善血管性痴呆患者中医证候表现及日常生活能力修正量表(ADL)评分。还不能认为中药可改善血管性痴呆患者简易智力状态速检表(MMSE)评分。[结论]目前中药治疗血管性痴呆的疗效及安全性的证据尚不够充分,尚需进行设计合理、执行严格、多中心大样本的随机对照试验。

Abstract:

[Objective] To evaluate the effectiveness and safety of the traditional Chinese medicine in treating vascular dementia systematically. [Methods] Correlative articles were searched by internet and manually. Using the method described in the Cochrane Reviewer’s Handbook 4.2.2 the quality of the articles and the analysis of the data were performed. [Results] 14 researches were brought into this investigation and the Jadad score estimation was carried out. Meta analysis was performed with RevMan4.2. We found that the Chinese medicine could improve the score of the syndrome of TCM and activities of daily living Scale (ADL) but not the scores of Mini-Mental State Examination Scale (MMSE) of the patients. [Conclusions] The evidences of therapeutic effects and safety of Chinese medicine in treating vascular dementia are still not sufficient. The articles of randomized and with controlled trial, reasonably designed, strictly carried out and obtained from multi-centers with large samples are needed.