| 摘要: |
| [目的]以去势大鼠为研究对象,通过观察骨密度和骨代谢相关的生化指标的变化以探讨"益肾养肝口服液"主药山茱萸的主要有效成分——山茱萸总苷对骨质疏松症的治疗机制。[方法]将50只Wister大鼠随机分为5组,即假手术组、模型组、山茱萸总苷高剂量组、山茱萸总苷中剂量组及山茱萸总苷低剂量组。造模后,山茱萸总苷组依剂量每天灌胃给药。以上各组处理60d,第61天取血,检测血钙(Ca)、血磷(P)、雌二醇(E2)。各组大鼠在灌胃满3个月后取股骨,进行骨密度实验。[结果]山茱萸总苷各剂量组雌二醇(E2)相对于模型组均明显提高,各组的血钙(Ca)、血磷(P)无明显差异。山茱萸总苷各剂量组骨密度明显优于模型组。[结论]山茱萸总苷对去势后大鼠的骨代谢和骨密度有良性调整作用。 |
| 关键词: 山茱萸总苷 骨质疏松 骨代谢 骨密度 |
| DOI：10.11656/j.issn.1672-1519.2007.04.29 |
| 分类号: |
| 基金项目:国家教育部课题资助项目(00139) |
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| Effect of cornel total glycoside on bone metabolism and bone density in caponized rats |
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LI Ping1, LI Jing2, WANG Hui-ming3
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1.Tianjin Nankai Hospital, Tianjin 300100, China;2.Tianjin University of TCM, Tianjin 300193, China;3.Tianjin Hospital of TCM, Tianjin 300140, China
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| Abstract: |
| [Objective] To explore the mechanism of cornel total glycoside,the main effective component in Yishen Yanggan for oral use,in treating osteoporosis. [Methods] Wistar rats were randomly divided into five groups: sham operated group,model group,the high,middle and low dosage of cornel total glycoside group. Ca,P,E2 were determined and bone density experiment was carried out. [Results] The E2 content and bone density of cornel total glycoside group were obviously higher than that of model group. The blood Ca and P of cornel total glycoside group had not obvious difference when compared with that of model group. [Conclusions] The cornel total glycoside has bitter regulative effect on bone metabolism and bone density of caponized rats. |
| Key words: cornel total glycoside osteoporosis bone metabolism bone density |
