| 摘要: |
| [目的]建立一种新的系膜增生性肾炎肾小管间质损害模型,并观察肾疏宁的保护作用。[方法]在系膜增生性肾炎(MsPGN)模型基础上,延长造模时间至12～16周,使其自然发展成肾小管间质损害模型,观察肾疏宁对进展性肾小管间质损害的保护作用,并设苯那普利为阳性对照组。[结果]随着造模时间的延长,模型组肾小管间质损害逐渐加重,肾疏宁及苯那普利组损伤程度明显减轻。[结论]系膜增生性肾炎中肾小管间质损害模型成功,中药肾疏宁对肾小管间质损害具有明显的保护作用。 |
| 关键词: 系膜增生性肾炎 肾小管间质损害 肾疏宁 模型 |
| DOI：10.11656/j.issn.1672-1519.2007.04.32 |
| 分类号: |
| 基金项目:自选课题,已通过天津市科委成果鉴定,成果鉴定号为津20070577 |
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| Establishment of Tubulointerstitial Lesion Model in Rat with Mesenteric Proliferative Glomerulonephritis and the Protective Effect of Shenshuning(SSN) |
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LI Guo-xia1, HUANG Wen-zheng2, ZHU Xiao-di2
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1.The International College of Integrated Traditional Chinese Medicine and Western Medicine of Tianjin Medical University, Tianjin 300070, China;2.The First Affiliated Hospital to Tianjin University of TCM, Tianjin 300193, China
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| Abstract: |
| [Objective] To establish a new animal model with progressive tubulointerstitial injury (TⅡ) in rats with Mesenteric proliferative glomerulonephritis and observe the protective effect of Shenshuning (SSN). [Methods] After inducing of Mesenteric proliferative glomerulonephritis (MsPGN) the sick rats were allowed survived till 12th -16th weeks and so producing a model tubulointerstitial lesion naturally. With this model the protective effect of the herbal medicine SSN was observed. At the same time,benazepril served as control. [Results] The tubulointerstitial injury was aggravated gradually along with the extension of time in model of rats. SSN and benazepril could distinctly relieve the tubulointerstitial injury. [Conclusions] The model with tubulointerstitial injury has successfully been estalished in rats with mesenteric proliferative glomerulonephritis. The herbal medicine SSN has exhibited distinct protective effect against the tubulointerstitial injury. |
| Key words: mesenteric proliferative glomerulonephritis tubulointerstitial lesions Shenshuning Model |
