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| 黄连解毒汤中栀子苷在大鼠体内的药动学研究 |
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肖学凤1, 乔晓莉2, 高岚1, 张军平3, 孙瑜1
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1.天津中医药大学中药学院, 天津, 300193;2.天津市南开医院, 天津, 300100;3.天津中医药大学第一附属医院, 天津, 300193
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| 摘要: |
| [目的]探讨黄连解毒汤中栀子苷在大鼠体内的药动学。[方法]大鼠灌胃给药,取血经处理后采用高效液相色谱(HPLC)法测定栀子苷含量。[结果]大鼠灌胃黄连解毒汤后,体内栀子苷的药-时曲线符合二室开放模型,药动学参数为:分布速率常数(α)=(0.03±0.01)/min,消除速率常数(β)=(0.0006±0.0002)/min,二室模型分布相的半衰期(t1/2α)=(79.02±22.38)min,二室模型消除相的半衰期(t1/2β)=(13031.81±8817.76)min,达峰时间(T(peak))=(99.46±28.73)min,血药峰浓度(Cmax)=(5.02±1.52)mg/L,血药浓度-时间曲线下面积(AUC)=(69334.66±15565.92)mg/(L·min)。[结论]明确了黄连解毒汤中栀子苷在大鼠体内的药动学过程,为黄连解毒汤的临床应用提供可参考的依据。 |
| 关键词: 黄连解毒汤 栀子苷 高效液相色谱法 药动学 |
| DOI：10.11656/j.issn.1672-1519.2008.04.26 |
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| Pharmacokinetic study of jasminoidin in Huanglianjiedu decoction in rats |
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Xiao Xuefeng,Qiao Xiaoli,Gao Lan
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1.Tianjin University of TCM, Tianjin 300193, China;2.Tianjin Nankai Hospital, Tianjin 300100, China
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| Abstract: |
| [Objective] To study the pharmacokinetics of Jasminoidin in Huanglianjiedu Decoction in rats. [Methods] HPLC detection was used to determine the Jasminoidin levels in biological samples. [Results] After giving Jasminoidin orally in rats, the plasma concentration-time course fitted well to two-compartment model and with following pharmacolinetic parameters: α=(0.03±0.01)/min, β=(0.000 6±0.000 2)/min,t1/2α=(79.02±22.38) min,t1/2β=(13 031.81±8 817.76) min,T(peak)=(99.46±28.73) min,Cmax=(5.02±1.52) mg/L,AUC=(69 334.66±15 565.92) mg/(L·min). [Conclusion] The pharmacokinetic characteristics of Jasminoidin in Huanglianjiedu Decoction in rats was identified, providing evidence for clinical medication of Huanglianjiedu decoction. |
| Key words: Huanglianjiedu decoction jasminoidin HPLC pharmacokinetic |
