化瘀降浊合剂对代谢综合征患者糖脂代谢的影响

Effect of Huayu Jiangzhuo mixture on glycolipid metabolism in patients with metabolic syndrome

关键词:  代谢综合征  糖脂代谢  化瘀降浊合剂

Key words:  metabolic syndrome  glycolipid metabolism  HuaYu JiangZhuo mixture (HYJZM)

摘要:

[目的]观察化瘀降浊合剂对代谢综合征(MS)患者的糖脂代谢的影响。[方法]采用随机平行对照的方法,将70例MS者分为2组,分别给予化瘀降浊合剂和罗格列酮进行干预12周,治疗前后分别对临床症状积分、肥胖度、血糖、血脂和血压变化情况以及不良反应进行了观察。[结果]化瘀降浊合剂可有效改善患者的临床症状,明显优于对照组;有效降低餐后2h血糖;显著降低总胆固醇、甘油三酯和低密度脂蛋白水平;轻度降低收缩压并可改善脉压;未见明显不良反应。[结论]化瘀降浊合剂可有效纠正代谢综合征患者的糖脂代谢紊乱。

Abstract:

[Objective] To observe the clinical effect of HuaYu JiangZhuo Mixture (resolving blood stasis and descending the turbid, HYJZM) on glycolipid metabolism in patients with metabolic syndrome (MS). [Methods] Seventy patients with MS who met with defined criteria were randomly divided into two groups: HYJZM-treated group and Western medicine-treated group. Patients in both groups were treated with HYJZM or Rosiglitazone for 12 weeks. Clinical symptom integral, plasma glucose, blood lipid, blood pressure and side-effects were observed before and after treatment in two groups. [Results] The clinical manifestation of HYJZM-treated group was improved significantly. Hyperglycemia and lipid metabolism disturbance were improved in both groups and there was no statistical significance between these two groups. Blood pressure in both groups was slightly lowered. Pulse pressure was decreased in HYJZM-treated group. No obvious adverse reaction and side effect were observed in HYJZM-treated group. [Conclusion] HYJZM can alleviate glycolipid metabolism disturbance in patients with metabolic syndrome.