中医药醒脑散治疗老年性痴呆的临床研究

Clinical study on treating senile dementia with chinese herb powder with effect of restoring consciousness

关键词:  醒脑散  老年性痴呆  浊毒  开通玄府  泄浊解毒

Key words:  XNS  senile dementia  turbid and poison  open sweat pores  expelling turbid urine and removing poisonous substances

摘要:

[目的]观察中药痴呆方醒脑散(XNS)对老年性痴呆的治疗效果。[方法]根据美国精神病学会第3版《精神病的诊断和统计手册》(ASM-Ⅲ)和国际疾病分类标准(ICD-10)诊断标准选择老年性痴呆病例,随机分成两组:观察组以XNS治疗2-3个疗程;对照组用石杉碱甲治疗。用智力状态量表(MMSE)、日常生活能力量表(ADL)和长谷川痴呆量表(HDS)的积分变化判断两组的总疗效和各组治疗前、后的疗效。[结果]MMSE的评分示观察组总有效率为88.1%,对照组总有效率为91.4%,两组间无显著性差异(P>0.05),两组治疗前后MMSE、HDS积分均显著增加(P<0.01),ADL积分显著降低(P<0.01),但组间比较无显著性差异(P>0.05)。[结论]以开通玄府,流通气液,泻浊解毒立法的痴呆方醒脑散对老年性痴呆的治疗具有可靠的效果,值得进一步研究。

Abstract:

[Objective] To observe the curative effects of the Xingnaosan (powder of restoring consciousness, XNS) in treating Senile Dementia. The main function of XNS was to open sweat pores, circulate fluid in body, expel turbid urine and remove poisonous substances. [Methods] The choosing of senile dementia cases was based on the diagnostic standards of ASM-Ⅲ and ICD-10. The patients of two groups were selected randomly: the study group was treated with XNS for two to three treatment periods; the control group was treated by huperzine A. The general curative effects and the curative effects before and after treatment of both groups were evaluated by MMSE, ADL and HDS scale.[Results] According to the grading of MMSE, the effective rate of the treatment group was 88.1% while that of control group was 91.4%. There wasn’t obvious difference between the patients of two groups (P>0.05). Both the MMSE and HDS integrals before and after treatment were increased dramatically (P<0.01); the ADL integrals was decreased dramatically (P<0.01); but there wasn’t obvious difference between groups (P>0.05). [Conclusion] XNS has reliable effects in treating senile dementia. It is worthy of further exploring.