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| 脑白质疏松轻度认知障碍病例对照研究 |
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陈宝鑫1, 张允岭1, 金香兰1, 陈志刚1, 郭蓉娟1, 侯小兵1, 高芳1, 戴中2, 柳洪胜2, 谢颖桢3, 王麟鹏4, 郭静4
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1.北京中医药大学东方医院神经内科, 北京, 100078;2.北京大学人民医院, 北京, 100044;3.北京中医药大学附属东直门医院, 北京, 100700;4.首都医科大学附属北京中医医院, 北京, 100010
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| 摘要: |
| [目的]探讨脑白质疏松轻度认知障碍的危险因素和临床特征。[方法]以年龄、性别为匹配条件,选择脑白质疏松(LA)轻度认知障碍患者与脑白质疏松无认知障碍患者各35例,进行病例对照研究。[结果]Logistic逐步回归分析显示LA轻度认知障碍的发病主要与文化程度、健康锻炼、脑力劳动、中风家族史、高脂血症相关,OR值分别为0.395,0.278,0.404,2.865,5.988,其中与文化程度、健康锻炼、脑力劳动呈负相关。LA有认知障碍(CI)组在计算能力、延时记忆、视空间能力方面明显低于LA无CI组(P<0.01);LA有CI组更常见烦躁、口干咽燥、双目干涩、肢倦身重、口中黏腻、善太息、潮热盗汗、咳笑时遗尿等症状;两组均普遍存在气血阴阳的亏虚和痰、瘀、火、郁等证候要素,多个证候要素并存。[结论]受教育程度高、健康锻炼、脑力劳动是认知功能的保护因素。中风家族史、高脂血症是认知障碍的危险因素。LA轻度认知障碍涉及多个认知域的损害;LA轻度认知障碍病机复杂,虚实并见。 |
| 关键词: 脑白质疏松 轻度认知障碍 病例对照 |
| DOI：10.11656/j.issn.1672-1519.2008.06.04 |
| 分类号: |
| 基金项目:首都医学发展科研基金联合攻关项目(SF-2005-3);2008年中医药行业科研专项(200807011);211工程重点学科建设项目;北京市新医药学科群建项目(xk100270569) |
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| Controlled study on the leukoaraiosis with mild cognitive impairment |
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CHEN Bao-xin,ZHANG Yun-ling,JIN Xiang-lan
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Dongfang Hospital of Beijing University of TCM, Beijing 100078, China
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| Abstract: |
| [Objective] To investigate the risk factors and clinical features of leukoaraiosis(LA) with mild cognitive impairment. [Methods] Case-controlled study was adopted in the study in 35 patients of LA with mild cognitive impairment matched in age and sex with 35 patients of LA without cognitive impairment. [Results] The logistic regression analysis of the multiple factors (backward method) showed that the OR of education level, exercise, mental work, family history of stroke and hyperlipidemia were 0.395, 0.278, 0.404, 2.865, 5.988. There was negative correlation between cognitive impairment and education level, exercise, mental work. The patients of LA with mild cognitive impairment had lower score of calculating ability, short-term memory, visual-spatial ability. Symptoms as follows were more fre-quent in the group of LA with mild cognitive impairment:dysphoria, dry mouth, dry eyes, heavy body, sticky and greasy in mouth, sighing, tidal fever and night sweating, enuresis when cough and laugh happened. The deficiency of qi, blood, yin, yang and phlegm, stagnation blood, fire, depression were equally exist in the two groups. [Conclusion] High education level, mental work and exercise are protecting factors of cognition, while family history of stroke and hyperlipidemia are risk factors. There was more than one cognitive domain disorder among the patients of LA with cognitive impairment. The pathogenesis of LA with mild cognitive impairment are complicated with both deficiency and excess existed. |
| Key words: Leukoaraiosis mild cognitive impairment case-controlled study |
