天麻钩藤饮对肾血管性高血压大鼠血压的影响

Effect of Tianma Gouteng decoction on the blood pressure in rats with renal angiogenic hypertension

关键词:  天麻钩藤饮  肾血管性高血压  血压

Key words:  Tianma Gouteng Decoction  renal angiogenic hypertension  blood pressure

摘要:

[目的]探讨天麻钩藤饮对肾血管性高血压大鼠血压的影响。[方法]48只雄性SD大鼠随机分为假手术组、模型组、卡托普利组和天麻钩藤饮组,每组12只。造模后第5周开始给药,连续治疗8周。然后观察天麻钩藤饮降压的作用。[结果]造模4周后,模型组大鼠血压明显上升(P<0.001),左肾质量(LK)和LK/RK值比假手术组明显降低(P<0.001),而右肾质量(RK)则显著增高(P<0.001),说明动物模型复制成功。8周干预治疗后,卡托普利组和天麻钩藤饮组大鼠血压均下降至达到或接近正常血压水平(P<0.01),而卡托普利的降压效果要优于天麻钩藤饮(P<0.05)。[结论]天麻钩藤饮能够明显降低肾性高血压大鼠的血压水平。

Abstract:

[Objective] To explore the effects of Tianma(RHIZOMA GASTRODIAE) Gouteng(RAMULUS UNCARIAE CUM UNCIS) decoction on blood pressure in rats with renal angiogenic hypertension. [Methods] Forty-eight male SD rats were randomly divided into the sham-operation group, the model group, the captopril group and the Tianma Gouteng decoction group. Five weeks after modeling, the rats were treated with drugs and persisted for eight weeks. The BP in every group was determined to confirm the effect of decreasing blood pressure. [Results] After four weeks, the blood pressure of the model group rats was obviously ascended (P<0.001), left kidney weight (LK),LK/RK descended(P<0.001) and right kidney weight(RK) was obviously increased(P<0.001), these all confirmed that the modeling was succeeded. After 8 weeks of treatment, the blood pressure level of the captopril and the Tianma Gouteng Decoction group decreased or closed to normal blood pressure (P<0.01). The effect of descending blood pressure of captopril was better (P<0.05). [Conclusion] Through the research, we confirmed that Tianma Gouteng Decoction can decrease blood pressure in rats with renal angiogenic hypertension.