穴位埋线对肥胖模型大鼠瘦素水平及血脂的影响

Effects of catgut-embedding at acupoint on contents of leptin and blood fat in obese rats

关键词:  肥胖症  穴位疗法  埋线  瘦素

Key words:  obesity  point therapy  catgut-embedding  leptin

摘要:

[目的]探讨穴位埋线对肥胖的治疗机制。[方法]采用高糖高脂饮食喂养建立肥胖模型大鼠。将造模成功的36只大鼠,随机分为3组。埋线组12只行埋线治疗,针刺组12只行针刺治疗,模型组12只及普通喂养的正常组12只不作特殊处理。在治疗4周后第2天处死,观察各组大鼠血清瘦素、下丘脑瘦素、体质量、体长、Lee’s指数及血脂的变化。[结果]肥胖大鼠的体质量、Lee’s指数及血清瘦素水平明显高于正常大鼠,下丘脑瘦素明显低于正常组(P<0.01)。穴位埋线取得良好的减肥作用的同时,能使肥胖大鼠血清瘦素明显下降及下丘脑瘦素明显升高,明显降低甘油三酯(TG)及总胆固醇(CHOL)(P<0.05)。[结论]穴位埋线对肥胖机体血脂、中枢及外周瘦素有良性调节作用。

Abstract:

[Objective] To discuss the treatment mechanisms of catgut embedding at acupoint of Obesity.[Methods] thirty-six obese ratsinduced with feeding high glucose and high fat diet were randomly divided into three groups.The 12 rats of Group 1 (catgut embedding)were only treated by catgut embedding at acupoint;12 rats of Group 2 (acupuncture) were treated by acupuncture only;12 rats of Group 3 (model) and the other 12 rats of group 4 (fed with ordinary diet) were not given any treatment.Four weeks later, all the rats were killed andthe change of the serum leptin, the hypothalamus leptin, the body weight, the stem length, the Lee’s index, and the blood fat were observed.[Results] The body weight, the Lee’s index and the serum leptin level of obese rats were obviously higher than those of the normalrats, while the hypothalamus leptin of obese rats was obviously lower than that of the normal rats (P<0.01).Catgut embeding at acupointhad good anti-obesity action.It could obviously lower the serum leptin, the triglyceride (TG) and the cholesterol (CHOL) of obese rats, andraise the hypothalamus leptin of obese rats (P<0.05).[Conclusion] Catgut embedding at acupoint has active effect on the obese organism‘s blood fat, center leptin and periphery leptin.