| 摘要: |
| [目的]观察中药补肾活血方对妊娠大鼠胚泡着床率的影响。[方法]选用妊娠SD大鼠随机分为空白组、模型组和中药低、中、高剂量组,于妊娠第5天扫描电镜观察各组子宫内膜胞饮突发育情况,妊娠第10天计数各组大鼠胚泡着床数。[结果]模型组子宫内膜表面未见明显的胞饮突发育,表现为增生早期的子宫内膜变化,中药中、高剂量组可见发育中的胞饮突,发育形态明显超前于模型组,接近于空白组;模型组胚泡着床数显著低于空白组(P<0.01),中药中、高剂量组胚泡着床数显著高于模型组(P<0.01)。[结论]临床用量的补肾活血方能明显改善大鼠子宫内膜表面胞饮突的发育,有助于子宫内膜容受性的建立,从而最终提高胚泡的着床率。 |
| 关键词: 补肾活血方 胞饮突 子宫内膜容受性 |
| DOI：10.11656/j.issn.1672-1519.2009.03.29 |
| 分类号: |
| 基金项目:天津市高等学校科技发展基金项目(编号:20050301) |
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| Study of Bushen Huoxue Prescription on increasing blastocyst nidation rate in pregnancy mice |
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WANG Ya-nan1, SONG Dian-rong2, LIU Ya-qin1
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1.Tianjin University of TCM, Tianjin 300193, China;2.The Second Affiliated Hospital of Tianjin University of TCM, Tianjin 300150, China
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| Abstract: |
| [Objective] To observe the effect of Bushen Huoxue prescription on blastocyst nidation in pregnancy mice. [Methods] SD pregnancy mice were randomly divided into control group,model group,low-dose treat group(L-D),middle-dose treat group(M-D) and high-dose treat group(H-D). On the fifth day of pregnancy(Pd5),development of endometrial pinopodes was determined by scanning electron microscopy. On Pd10,the numbers of implanted blastocyst was counted. [Results] Developing pinopodes of endometrial surface were bad in model group as endometrial of early proliferative phase. Developed pinopodes,however,were observed in M-D and H-D treat group compared with control group. The number of implanted blastocysts in model group was significantly lower than that of control group(P<0.01),and M-D and H-D treat group were higher than model group(P<0.01). [Conclusion] It is suggested that Bushen Huoxue prescription can improve the pinopodes developing in endometrial surface helped to eventually the establishment of reception of the endometria and improve the blastocyst implantation rate. |
| Key words: Bushen Huoxue prescription pinopodes endometrial receptivity |
