脑梗死急性期证候要素与血脂代谢紊乱的相关性研究

Study on relationship between elements of TCM syndromes and metabolism of blood lipid in patients with acute cerebral infarction

关键词:  脑梗死急性期  证候要素  血脂  氧化低密度脂蛋白

Key words:  acute cerebral infarction  syndrome element  blood fat  low density lipoprotein

摘要:

[目的]探讨脑梗死急性期患者证候要素与血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、氧化低密度脂蛋白(Ox-LDL)等动脉粥样硬化危险因素的相关性。[方法]前瞻性的收集脑梗死急性期患者临床资料166例,根据入院时的四诊信息对证候要素予以赋分,同时检测发病72hTC、TG、HDL-C、LDL-C、Ox-LDL数值,应用统计软件SPSS研究证候要素与血脂代谢紊乱的相关性。[结果]脑梗死急性期证候要素出现频数最高为风91例次,占55.2%,阴虚阳亢出现最少13例次,占7.9%。单一证候要素31例,占18.8%,相兼证候要素共118例,占71.5%;女性TC、LDL-C水平明显高于男性;年龄≥60岁TG、LDL-C、Ox-LDL与年龄<60岁患者相比有明显差异(P<0.05)。不同证候要素间各项血脂水平无明显差异;风与Ox-LDL成正相关;火与TG成负相关;阴虚阳亢与TC成正相关。[结论]在中风病发病过程中普遍存在血脂代谢异常现象,各证候要素分值与血脂代谢紊乱之间存在相关性,为进一步揭示中风病的发病机制提供依据。

Abstract:

[Objective] To study on the relationship between elements of TCM syndromes and metabolism disorder of blood lipid in patients with acute cerebral infarction. [Methods] One hundred and sixty-six patients with ACI were collected,scored with elements of TCM Syndrome according to hospital patient information and detected the serum level of triglyeeride(TG), totaleholesterol(TC),Low-density lipoprotein (LDL-C),High density lipoprotein (HDL-C),Oxidized low density lipoprotein (Ox-LDL); The correlation between TCM syndromes and metabolism disorder of blood lipid was researched. [Results] The highest occurrence frequency syndromes was the wind syndrome, occupying 55.2%, the least occurrence frequency syndromes was yin deficiency syndrome, occupying 55.2%; Single elements of TCM syndromes had 31 cases, occupying 18.8%; Multiple syndromes had 118 cases, occupying 71.5%; There was a statistic difference in TC, LDL-C between female and male patients (P<0.05). There was a statistic difference in TG, LDL-C, Ox-LDL between patients more than 60-year in age and those less than 60-year-old. The wind syndrome was correlated to Ox-LDL, the fire-heat syndrome was negatively correlated with TG and the yin deficiency syndrome was correlated to TC. [Conclusion] There are ubiquity of metabolism disorder of blood lipid in the pathogenesis of acute cerebral infarction. And the correlation exists between elements of TCM syndromes and metabolism disorder of blood lipid. It can provides basis for revealing the pathogenesis of ACI.