辨病与辨证治疗非酒精性脂肪性肝炎临床疗效研究

Clinical observation on therapeutic effect of nonalcoholic steatohepatitis through bianbing and bianzheng

关键词:  非酒精性脂肪性肝炎  辨病  辨证  疗效观察

Key words:  nonalcoholic steatohepatitis  bianbing  bianzheng  clinical observation on therapeutic effect

摘要:

[目的]观察辨病与辨证治疗非酒精性脂肪性肝炎(NASH)的临床疗效。[方法]将确诊为NASH患者120例,随机分为两组,辨病组给予疏肝丸;辨证组在疏肝丸基本方的基础上根据辨证进行加减,两组疗程均为3个月。观察治疗前后患者症状、肝功能、血脂及肝脏彩超变化。[结果]辨证组总有效率为85.0%;对照组总有效率为81.7%。[结论]应用疏肝丸基本方及其加减治疗NASH均有明显疗效,并未发现辨证与辨病治疗的区别。

Abstract:

[Objective] To observe the clinical effect in treating nonalcoholic steatohepatitis(NASH) through bianbing(disease differentiation) and bianzheng(syndrome differentiation). [Methods] One hundred and twenty subjects with NASH were randomly divided into two groups. The patients in bianbing group took Shugan Pills, and those in bianzheng group were treated with pills modified from Shugan Pills according to Traditional Chinese Medicine Syndrome type. All these patients were followed up 3 months to observe the changes in symptom, liver function, blood-lipid and USG. [Results] Thirty one cases were cured, 15 cases were excellent, 5 cases were efficacious, 9 cases were ineffective, and the cure rate was 85.0% in bianzheng group. Twenty eight cases were cured, 14 cases were excellent, 7 cases were efficacious, and 11 cases were ineffective, and the cured rate was 81.7% in the bianbing group. There were significant differences in the total effective rates between before and after therapy in both of the two groups (P<0.01). But there was no significant difference between the cure rates of two groups (P>0.05). [Conclusion] Both Shugan Pills and its modified pills has obvious clinical effect in treating NASH, and there was no significant difference between the two methods.