| 摘要: |
| [目的]建立黄芩苷缓释片释放度的紫外测定方法,并考察其体外释放机制。[方法]采用紫外分光光度法测定黄芩苷缓释片的体外释放度,并对影响释药的因素进行了单因素考察。[结果]羟丙甲纤维素(HPMC)的规格和用量对释药速率有显著影响,黄芩苷缓释片的体外释放曲线基本符合Higuchi方程。[结论]该研究方法简便、快速,体外释放度显示黄芩苷缓释片处方设计比较合理,可进一步研发。 |
| 关键词: 黄芩苷 缓释片 释放度 |
| DOI：10.11656/j.issn.1672-1519.2009.05.33 |
| 分类号: |
| 基金项目:国际科技合作计划项目(2007DFC31670);国家科技支撑计划项目(2007BAI47B01) |
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| Study on extracorporal dissolution of baicalin extended-release tablets |
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GAO Guo-yi1, LIU Zhi-dong2, ZHAO Zheng1
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1.Research institute of TCM, Tianjin University of TCM, Tianjin, 300193, China;2.Tianjin University of TCM, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin, 300193, China
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| Abstract: |
| [Objective] To establish a UV method to determine the dissolution of baicalin extended-release tablets and determine its release mechanism in vitro. [Methods] The extracorporal dissolution of baicalin extended-release tablets was determined by UV method,the factors that influence drug release were determined by single factor investigation. [Results] Both qualification and dosage of HPMC had significant influence on the rate of drug release. The release curve in vitro of baicalin extended-release tablets fitted Higuchi equation fundamentally. [Conclusion] The UV method is simple and quick,the extracorporal dissolution show that the prescription of the extend-ed-release tablets is reasonable relatively,it was worthy for further research. |
| Key words: baicalin extended-release tablets dissolution |
