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| 不同促渗剂对黄芩苷离体鼠皮透过行为的影响 |
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赵诤1,2, 宋西卫1,2, 刘志东1,2
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1.天津中医药大学中医药研究院, 天津, 300193;2.天津中医药大学现代中药发现与制剂技术教育部工程研究中心, 天津, 300193
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| 摘要: |
| [目的]研究辛酸/癸酸甘油酯(Lab)、二乙二醇单乙基醚(TransP)以及丙二醇(PG)对黄芩苷透皮行为的影响。[方法]采用改良Franz扩散池,考察Lab、TransP和PG在不同浓度下,对黄芩苷离体鼠皮透过行为的影响。[结果]与空白组相比,3%TransP与5%PG的表观渗透系数增加了3.15和3.05倍,有差异(P<0.05),几种促渗剂对黄芩苷透过的增渗作用依次为3%TransP>5%PG>7%PG>5%TransP>7%TransP>3%PG>1%TransP>10%PG>5%Lab。[结论]3%TransP与5%PG的促渗效果比较明显,可进一步应用于黄芩苷透皮制剂中。 |
| 关键词: 促渗剂 黄芩苷 影响 |
| DOI：10.11656/j.issn.1672-1519.2009.05.32 |
| 分类号: |
| 基金项目:国际科技合作计划项目(2007DFC31670);国家科技支撑计划项目(2007BAI47B00) |
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| The effects of different penetration enhancers on transdermal behavior of Baicalin in rat in vitro |
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ZHAO Zheng1,2, SONG Xi-wei1,2, LIU Zhi-dong1,2
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1.Tianjin University of TCM, Research institute of Traditional Chinese Medicine, Tianjin, China;2.Tianjin University of TCM, Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin, 300193, China
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| Abstract: |
| [Objective] To study the effects of Lab,Trans P and PG on the transdermal behavior of Baicalin in rat. [Methods] The Franz modified diffusion chamber was applied for evaluating the effect of different concentrations of each penetration enhancer (PE) on the permeability of Baicalin in vitro. [Results] Compared with control (P<0.05),3% Trans P and 5% PG could increase the apparent permeability as much as 3.15 and 3.05 folds. The penetration rate with the PE:3%Trans P>5%PG>7%PG>5%TransP>7%TransP>3%PG>1% TransP>10%PG>5%Lab. [Conclusion] The enhance effect of 3%TransP and 5%PG is significant,and is likely to apply in the further re-search. |
| Key words: penetration enhancer Baicalin |
