中药联合尿激酶溶栓治疗急性脑梗死200例回顾分析

A retrospective analysis on the clinical effect of traditional Chinese medicine combined with urokinase thrombolysis in 200 patients with acute cerebral infarction

关键词:  中药联合溶栓:急性脑梗死  回顾性分析

Key words:  traditional Chinese medicine combined with thrombolytic therapy  acute cerebral infarction  retrospective analysis

摘要:

[目的]回顾性分析中药联合尿激酶溶栓治疗急性脑梗死的近期及远期临床疗效。[方法]收集2001年1月—2005年12月间中药联合尿激酶溶栓治疗急性脑梗死患者200例,评价溶栓前后患者神经功能缺损情况;并通过电话随访方式,调查溶栓治疗后1a内患者再次梗死、出血、死亡等不良状况发生情况。统计各种中药在溶栓患者中的使用频次。[结论]100例中药联合小剂量尿激酶组总有效率为83.00%,100例单纯小剂量尿激酶组总有效率为71.00%。溶栓后1a内,中药联合小剂量尿激酶溶组其死亡、脑出血及再次梗死发生率均低于单纯使用小剂量尿激酶组。[结论]中药联合尿激酶治疗急性脑梗死疗效确切,两者具有协同作用,中西医联合溶栓具有较好的安全性。

Abstract:

[Objective] A retrospective analysis on the short and long term clinical effect of traditional Chinese medicine combined with urokinase thrombolysis in treating acute cerebral infarction was made. [Methods] Two hundred patients with acute cerebral infarction from January 2001 to December 2005 were selected and the degree of neurologic impairment before and after thrombolytic therapy was evaluated. The occurrences of adverse events within one year after thrombolytic therapy were investigated through follow-up with telephone, such as recurrence of cerebral infarction, cerebral hemorrhage and death. We also counted the frequency of every traditional Chinese medicine using in the therapeutic process. [Results] The total effective rate of 100 cases in the group of traditional Chinese medicine combined with urokinase thrombolysis was 83.00%, and 71.00% in the group of small dose urokinase thrombolysis only. Within one year, the recurrence incidences of cerebral infarction, cerebral hemorrhage and death in the group of traditional Chinese medicine combined with urokinase thrombolysis were all lower than that in the group of small dose urokinase thrombolysis only. [Conclusion] Traditional Chinese medicine combined with urokinase thrombolytic therapy has a definite therapeutic effect in treating acute cerebral infarction, and they have a synergistic effect. Thrombolytic therapy of integrated traditional Chinese and Western medicine has a better security in treating acute cerebral infarction.