银杏叶提取物EGB761对高胆固醇家兔肝质量和形态的影响

Effect of ginkgo biloba extract EGB761 on liver weight and morphology in hypercholesterolemia rabbits

关键词:  银杏叶提取物EGB761  脂肪肝  高胆固醇血症

Key words:  ginkgo biloba extract EGB761  fatty liver  hypercholesterolemia

摘要:

[目的]观察银杏叶提取物(EGB761)对高胆固醇家兔肝质量和形态的影响。[方法]参照D.Larry Sparks等方法复制高胆固醇血症家兔模型。采用50mg(/kg·d)EGB761灌胃3周,以辛伐他汀5mg(/kg·d)作为阳性对照药。评价肝体指数,观察肝脏的形态学变化。[结论]EGB761可以有效降低肝体指数(P<0.01),与阳性药辛伐他汀疗效相比无显著性差异(P>0.05);大体和镜下形态学观察发现EGB761可以有效的改变脂肪变性肝脏的大体形态和组织学形态。[结论]EGB761可以有效防治高胆固醇血症所致脂肪肝的发生。

Abstract:

[Objective] To observe the effect of Ginkgo biloba extract EGB761 on liver weight and morphology in hypercholesterolemia rabbits. [Methods] The hypercholesterolemia in rabbit was induced by refer to D. Larry Sparks’methods. EGB761 was used to treat the rabbits at a dose of 50mg/kg/d and simvastatin, 5mg/kg/d, as a positive control drug. The index of liver and body was evaluated and the morphological changes of the liver were observed. [Results] Ginkgo biloba extract EGB761 could effectively reduce the liver body index (P<0.01) without significant difference compared to the effect of positive drug simvastatin (P>0.05). General and the microscope morphological observations found that EGB761 could effectively change the general form of fatty degeneration of the liver and histological patterns. [Conclusion] Ginkgo biloba extract EGB761 can effectively prevent and treat fatty liver induced by hypercholesterolemia.