| 摘要: |
| [目的]观察针刺对局灶性脑缺血大鼠脑组织及血清白介素8(IL-8)含量的影响。[方法]以热凝法阻断一侧大脑中动脉造成大鼠局灶性脑缺血模型,采用放免法测定大鼠脑组织及血清IL-8含量。[结果]脑缺血后各时段模型组与同时段假手术组及正常组比较脑组织及血清IL-8显著升高(P<0.05,P<0.01);治疗后6、12、24、48h各时段针刺组与同时段模型组比较脑组织IL-8含量明显降低(P<0.01),6、12及48h针刺组血清IL-8含量显著低于同时段模型组(P<0.05,P<0.01)。[结论]针刺可能通过抑制缺血区脑组织IL-8的合成和分泌,调节血清IL-8的含量,抑制炎性细胞的黏附及浸润,从发挥脑保护作用。 |
| 关键词: 针刺 脑缺血 白介素-8 |
| DOI：10.11656/j.issn.1672-1519.2010.01.13 |
| 分类号: |
| 基金项目:国家自然科学基金资助课题(30672716) |
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| The influence of acupuncture on IL-8 in brain and serum of the rats with focal cerebral ischemia |
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GUO Yong-ming1, LIANG Xian-ru2
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1.Tianjin University of TCM, Tianjin 300193, China;2.The Affiliated Hospital of Armed Police Medical College, Tianjin 300261, China
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| Abstract: |
| [Objective] To observe the influence of acupuncture on the content of IL-8 in brain and serum of the rats with focal cerebral ischemia.[Methods] One lateral of the middle cerebral artery was obstructed with the thermocoagulation method to induce focal cerebral ischemia.The content of IL-8 in the brain and serum was measured with radio-immunologic method.[Results] Compared with the sham operation group and the normal group,the content of IL-8 in the brain and serum increased significantly at each time point after ischemia in the model group (P<0.05,P<0.01).Compared with the model group,IL-8 was decreased significantly in the acupuncture group in brain at 6,12,24 and 48 hours (P<0.01) and in serum at 6,12 and 48 hours (P<0.05,P<0.01) after acupuncture treatment.[Conclusion] Acupuncture may protect the brain through inhibiting synthesis and secretion of IL-8 in the ischemic tissue regulating the content of IL-8 in serum and inhibiting adhesion and infiltration of inflammatory cells. |
| Key words: acupuncture cerebral ischemia IL-8 |
