川芎嗪联合东莨菪碱治疗慢性阻塞性肺疾病加重期的临床研究

Clinical study on treating exacerbated stage of chronic obstructive pulmonary disease with tetramethylpyrazine combined with scopolamine

关键词:  东莨菪碱  慢性阻塞性肺疾病  川芎嗪

Key words:  scopolamine  tetramethylpyrazine  chronic obstructive pulmonary disease

摘要:

[目的]探讨川芎嗪联合东莨菪碱佐治慢性阻塞性肺疾病加重期的疗效。[方法]对65例慢性阻塞性肺疾病患者随机分为治疗组和对照组,两组均给予常规治疗,治疗组在常规治疗基础上,加用川芎嗪和东莨菪碱,7d为1个疗程。每天检测动脉血气分析,并与对照组比较。[结果]治疗前氧分压(PaO₂)、二氧化碳分压(PaCO₂)均无显著性差异(P>0.05)。治疗7d后治疗组治疗前后PaO₂、PaCO₂比较有统计学意义,治疗后PaO₂明显高于对照组(P<0.01),PaCO₂明显降低,两组差异有显著性。[结论]应用川芎嗪和东莨菪碱治疗慢性阻塞性肺疾病有显著疗效。

Abstract:

[Objective] To study the therapeutic effect and significance of tetramethylpyrazine combined with scopolamine in treating exacerbated stage of chronic obstructive pulmonary disease. [Methods] Sixty-five patients with chronic obstructive pulmonary disease were randomly divided into two groups:the treatment group (n=32) and the control group (n=33). The patients of two groups were received same basic treatment and the treatment group was given additional treatment with tetramethylpyrazine and scopolamine intravenously for seven days. The arterial blood gas analysis was examined in both groups every day and they were given inter-comparison. [Results] The PaO₂ and PaCO₂ didn’t change significantly before treatment of the two groups. After treatment for seven days,the PaO₂ was higher and PaCO₂ was lower in treatment group than that in control group,and there was statistical difference after treatment (P<0.01). [Conclusion] Tetram-ethylpyrazine combined with scopolamine has significant curative effect for patients with exacerbated chronic obstructive pulmonary disease.