中药“醒脑汤”直肠滴注在急性一氧化碳中毒后迟发性脑病的临床应用

Clinical application of Chinese medicine xingnao decoction by rectal infusion in treating delayed encephalopathy after acute carbon monoxide poisoning

关键词:  一氧化碳中毒  迟发性脑病  直肠滴注  醒脑汤

Key words:  carbon monoxide poisoning  delayed encephalopathy  rectum infusion  Xingnao decoction

摘要:

[目的]观察中药“醒脑汤”直肠滴注和单纯西药治疗中毒迟发性脑病的临床疗效。[方法]采用中药制剂“醒脑汤”直肠滴注给药,并配合西药静滴治疗一氧化碳(CO)中毒迟发性脑病急性期患者35例(治疗组),与常规西药治疗的35例(对照组)患者进行比较。[结果]治疗组总有效率比对照组组提高、平均住院天数比对照组组缩短(P<0.05),两组治疗前后智力残疾评分(AAMD)和简易智能量表(MMSE)评分差异均有显著性(P<0.01),治疗组AAMD、MMSE评分改善幅度较对照组差异有显著性(P<0.05)。[结论]中药“醒脑汤”直肠滴注操作简便,制剂可据证加减,抢救患者迅速、方便、显效,为发挥中药抢救CO中毒迟发性脑病患者提供了一种新方法、新剂型。

Abstract:

[Objective] To observe the effect of "Xingnao decoction" per rectum infusion and the Western medicine only in treating delayed encephalopathy after carbon monoxide poisoning.[Methods] Herbal Xingnao decoction was used to treat patients per rectum infusion combined with intravenous Western medicine to treat the delayed encephalopathy after acute CO poisoning.The effect of Thirty-five patients(treatment group),and thirty-five in conventional Western medicine group(control group) was compared.[Results] The total effective rate in treatment group compared with control group was significantly increased and the average length of stay in hospital was shorter than the control group(P<0.05),before and after treatment the difference of AAMD and MMSE score between these two groups was significant(P<0.01).[Conclusion] Chinese medicine "Xingnao soup" per rectal infusion was simple in procedure and the preparation can be modified with symptom.In saving patients the effect was quick,convenient with obvious efficacy.It provided a new method and new preparation of Chinese medicine in saving delayed encephalopathy after CO poisoning.