六君三子汤加减治疗AECOPDⅢ级80例疗效观察

The curative effect of modified liujunsanzi decoction on 80 patients with AECOPD Ⅲ

关键词:  慢性阻塞性肺疾病加重期Ⅲ级  中西医结合  肺功能  血气分析

Key words:  AECOPD Ⅲ level  integrative medicine  pulmonary function  blood gas analysis

摘要:

[目的]探讨中西医结合疗法对慢性阻塞性肺疾病加重期(AECOPD)Ⅲ级患者肺通气功能及血气的影响。[方法]80例患者随机分为中西医结合治疗组及西医治疗组。西医治疗组使用西药常规治疗,中西医结合治疗组在西医治疗组治疗基础上服六君三子汤加减治疗。[结果]西医治疗组及中西医结合治疗组均能有效改善用力肺活量(FVC%)、1秒用力呼气量(FEV1)占预计值百分比(FEV₁%)、最大通气量占预计值百分比(MVV%),降低二氧化碳分压(PCO₂),提高氧分压(PO₂),各指标治疗前后对比P<0.05。中西医结合治疗组较西医治疗组更能有效提高FVC%、MVV%、PO₂,降低PCO₂,两组治疗后比较P<0.05,但对FEV₁%改善无差异。[结论]中西医结合治疗AECOPD,能较好的改善COPD患者肺功能、提高血氧分压、降低二氧化碳分压,值得临床推广。

Abstract:

[Objective] The aim of this study was to evaluate the therapeutic effect of integrated traditional Chinese medicine and Western medicine for AECOPD Ⅲ level(chronic obstructive pulmonary disease with acute exacerbation of grade Ⅲ) by pulmonary function and blood gas.[Methods] Eighty patients of AECOPD Ⅲ level were randomly divided into integrated traditional Chinese medicine and Western medicine treatment group and Western medicine treatment only group.The patients of Western medicine treatment group were treated with conventional therapies.Integrated traditional Chinese medicine and Western medicine group with conventional therapies and liujun sanzi decoction.[Results] Both of integrated traditional Chinese medicine and Western medicine treatment group and Western medicine treatment group could improve FVC%,FEV₁%,MVV%,increase PO₂,lower PCO₂.Statistically significant differences were observed before and after treatment.Integrated traditional Chinese medicine and Western medicine treatment group was more effective than that of Western medicine treatment only group in increasing FVC%,MVV%,PO₂ and lowering PCO₂.Statistically significant differences were observed between two groups.No statistically significant differences were observed on FEV₁% between two groups.[Conclusions] Integrated traditional and Western medicine therapy in patients with COPD can improve pulmonary function better,increase blood oxygen,reduce carbon dioxide partial pressure and has clinical value.