| 摘要: |
| [目的]建立原料药头孢地嗪钠中聚合物含量的测定方法。[方法]用凝胶色谱柱,采用自身对照外标法,测定头孢地嗪钠原料中聚合物含量。[结果]头孢地嗪缔合物在17.83～178.26 g/L范围内,以及头孢地嗪聚合物在5.237～50.041 g/L范围内,与峰面积呈良好的线性关系。[结论]该方法操作简单,准确,灵敏度高。 |
| 关键词: 头孢地嗪钠 聚合物 凝胶色谱柱 自身对照外标法 |
| DOI：10.11656/j.issn.1672-1519.2011.03.30 |
| 分类号: |
| 基金项目: |
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| Determination of the polymers in Cefodizime Sodium for crude drugs |
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TAO Jun1, ZHANG Wen-yan2, WANG Nai-hao1
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1.Hebei Aoxing Group Pharmaceutical Development Limited Company, Xinle 050700, China;2.Health Department of Health Supervision Bureau of Hebei Province, Shijiazhuang 050051, China
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| Abstract: |
| [Objective] To establish the method for determination of the polymers in Cefodizime Sodium in crude Drugs.[Methods] The polymers analyzer was used with Sephadex G-10 column.The self control external standard method was used for quantitative analysis.[Results] The linear ranges of the associations in Cefodizime and the polymers in Cefodizime were 17.83～178.26 g/L and 5.237~50.041 g/L.[Conclusion] The method is simple,accurate and sensitive. |
| Key words: Cefodizime Sodium polymers Gelfiltratrion chromatograpy external standard method |
