半夏与茯苓在治疗糖尿病合并胃轻瘫中的作用

Effect of pinellia tuber and tuckahoe in treating diabetes combined with gastric paresis

关键词:  半夏  茯苓  糖尿病  胃轻瘫

Key words:  pinellia tuber  tuckahoe  diabetes  diabetic gastric paresis

摘要:

从《金匮要略》含有半夏与茯苓两药的5首方剂中,论述其在治疗糖尿病合并胃轻瘫中的作用。半夏对呕吐中枢有抑制作用,其所含葡萄糖醛酸的衍生物中有比葡萄糖醛酸强的抗马钱子碱、乙酰胆碱的作用外,还可以增加胃肠顺应性蠕动。茯苓含有钾盐,其对植物神经有明显的调节作用,似与抑制肾小管的重吸收功能有关。糖尿病合并胃轻瘫的患者主症除有疲劳乏力、恶心呕吐外,患者还有嗳气、胀气、食欲不振等症,治疗中加入半夏与茯苓有良好的疗效,可能与上述机制有关。

Abstract:

To illuminate the effect of pinellia tuber and tuckahoe in treating diabetes combined with gastric paresis with five prescriptions consisting of those two herbs cited from Synopsis of Golden Chamber.The following results have been proved by the modern pharmacological studies.Firstly,pinellia tuber could inhibit vomiting center;secondly,the derivatives of glucuronic acid in pinellia tuber were not only more effective than glucuronic acid in the antagonist effect of strychnine and acetylcholine,but also could enhance the peristaltic movement of gastrointestinal tract;thirdly,tuckahoe,which was rich in potassium,had obvious effects on the adjustment of autonomic nervous system and seemly related with the inhibitive function for reabsorption of renal tubules.The mechanism of the treating effects of pinellia tuber and tuckahoe for diabetic gastric paresis with main syndromes of nausea,vomiting,belching,distending abdomen and indigestion was probably relative to above mecahanisms.