穴位埋线对糖尿病大鼠脂代谢紊乱及胰岛素敏感性的影响

Effect of acupoint catgut embedding therapy on disturbance of lipid metabolism and sensitivity to insulin in diabetic rats

关键词:  穴位埋线  脂代谢紊乱  胰岛素敏感性  血管病变

Key words:  acupoint catgut embedding therapy  disturbance of lipid metabolism  sensitivity to insulin  angiopathy

摘要:

[目的]观察穴位埋线对糖尿病大鼠脂代谢紊乱及胰岛素敏感性的影响,探讨其防治糖尿病血管病变(DA)的机制。[方法]四氧嘧啶注射配合高脂饲料喂养建立动物模型,埋线治疗后,测定其血清甘油三酯(TG)、总胆固醇(TC)、氧化低密度脂蛋白(ox-LDL)、高密度脂蛋白(HDL)、载脂蛋白AI(ApoAI)、载脂蛋白B(ApoB)、脂蛋白a[Lp(a)]、一氧化氮(NO)、血浆内皮素(ET)、胰岛素敏感指数(ISI)等指标。[结果]糖尿病大鼠血清TG、TC、ox-LDL、ApoB、LP(a)、血浆ET含量升高,血清NO、ApoAI、HDL含量及ISI降低,埋线疗后,TG、TCo、x-LDL、ApoB、LP(a)、血浆ET含量显著降低,NO、ApoAI、HDL含量及ISI降低有统计学意义(P<0.05,P<0.01或P<0.001)。[结论]穴位埋线能增强胰岛素敏感性、纠正脂代谢紊乱、改善血管内皮功能,对DA具有防治作用。

Abstract:

[Objective] To explore the mechanism of prevention and treatment against diabetic angiopathy by observing the effect of acupoint catgut embedding therapy(ACET) on the disturbance of lipid metabolism and sensitivity to insulin in diabetic rats.[Methods] We established a model in rats with diabetes by intra-abdominal injection of alloxan and feeding with fatty feed.After treated with ACET,the serum triglyceride(TG),total cholesterol(TC),oxidation low density lipoprotein(ox-LDL),high density lipoprotein(HDL),apolipoproteinAI(ApoAI),apolipoproteinB(ApoB),lipoprotein(a) ,nitric oxide(NO),plasma endothelins(ET),insulin sensitivity indication(ISI),and so on were detected.[Results] Compared with the control group,the plasma ET,serum ApoB,TG,TC,ox-LDL,Lp(a) of model rats were increased,serum NO,ApoAI,HDL and ISI were decreased.After treating,the plasma ET,serum TG,TC,ox-LDL,ApoB,Lp(a) were decreased markedly,serum NO,ApoAI,HDL and ISI were increased obviously(P<0.05,P<0.01 or P<0.001).[Conclusion] ACET can prevent and treat DA effectively by reinforcing insulin sensitivity,correcting disturbance of lipid metabolism,and ameliorating the vessel endothelial function.