| 摘要: |
| [目的]采用正交实验优选清脑镇静颗粒的最佳处方。[方法]以颗粒剂吸湿率为指标,采用正交设计实验,对处方配比进行筛选。[结果]优化处方为:干浸膏粉:糊精:乳糖:微晶纤维素=10:2:3:2。优化后清脑镇静颗粒吸湿率较中药浸膏粉有明显降低。[结论]清脑镇静颗粒剂处方合理、工艺可行,符合颗粒剂的质量要求。 |
| 关键词: 清脑镇静颗粒剂 正交实验 吸湿率 处方优化 |
| DOI：10.11656/j.issn.1672-1519.2011.05.28 |
| 分类号: |
| 基金项目:国家科技支撑计划项目(2007BAI41B06) |
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| Optimization of prescription of Qingnao Zhenjing granules |
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WANG Long1, MA Li2, HAN Feng2
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1.Tianjin University of TCM, Tianjin 300193, China;2.Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
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| Abstract: |
| [Objective] To optimize the prescription for Qingnao Zhenjing granules by orthogonal design.[Methods] Moisture rate as an index,in order to optimize the dosage and ultimately determine the prescription,the orthogonal experimental design was used.[Results] The optimizing prescription contains :extracts powder: dioxide : lactose : microcrystalline cellulose=10:2:3:2.[Conclusion] The optimized prescription and technology is reasonable,and conform to the quality requirements of granules. |
| Key words: Qingnao Zhenjing granules orthogonal design moisture rate optimization of prescription |
