脑梗死大鼠模型的针刺效应综合评价数学模型的建构

Establishment of mathematical model in comprehensive evaluating effect of acupuncture in rats with cerebral occlusion

关键词:  脑梗死大鼠  针刺效应  综合评价  数学模型  权重系数  负指标  主成分-因子分析

Key words:  rat with MCAo  mathematical model  acupunctural effect  comprehensive evaluation  weight coefficient  negative index  principle-factor analysis

摘要:

[目的] 构筑脑梗死大鼠针刺效应综合评价数学模型,确定各指标的权重系数,比较各个指标权重系数对针刺效应的影响程度,并初步探讨针刺治疗脑梗死的可能机制。[方法] 引用负指标的概念,采用主成分-因子分析建立针刺效应的综合评价数学模型。[结果] 统计量F即为建构的脑梗死大鼠针刺效应综合评价数学模型。从模型的各个指标权重系数可知:微循环指标中的输入枝(A)管径和AV比值对于针刺效应的综合评价影响最大,其次是微血管数、坏死神经细胞率,影响最小的是梗死率。[结论] 通过数学模型可知针刺治疗脑梗死可能机制主要是通过改善大脑微循环(扩张输入枝管径、增大AV比值)、增加微血管数来实现的。该数学模型不仅为中医针灸的发展提供了新的研究思路和方法,同时也为今后作进一步的数据分析奠定了基础。并指出用数学模型来表达中医的科学内涵,是中医现代化的必由之路。

Abstract:

[Objective] To establish the mathematical model for comprehensive evaluating the effect of acupuncture in Wistar rat with middle cerebral artery occlusion (MCAo), ascertain the weight coefficients of indexes, compare the influence on the weight coefficients of indexes by acupuncture, and preliminarily explore the possible mechanism of acupuncture treatment for the cerebral infarction.[Methods] Using the concept of “negative-index”, the multi-element statistical analyses (such as the principal component analysis, factor analysis, etc.) were applied by SPSS18.0 to establish the mathematical model for comprehensive evaluating the effect of acupuncture. [Results] The statistic F in the mathematical model of the comprehensive evaluating the effect of acupuncture was established in rat with MCAo, the weight coefficient of each index ascertained, the statistic F was then formed: in microcirculation index, the caliber of afferent arteriole (A) and AV ratio value had the biggest influence on the comprehensive evaluation of acupuncture effect, the next was microvessel count, neutrocyte necrosis rate, …, the last one was infarction rate. [Conclusion] Through the mathematical model it is found that the possible mechanism of acupuncture treatment for cerebral infarction is to improve the cerebral microcirculation (properly expanding the caliber of afferent arteriole (A), enlarge AV ratio) and increase the microvessel count. It was pointed out that application of the mathematics model to express the essence of science is the only way for the modernization of traditional Chinese medicine. The establishment of the mathematics model of the comprehensive evaluating the effect of acupuncture could not only provide a new scientific research ideas and methods, but also lay a foundation for the further data analysis in the future.