吴茱萸性味药理学评价体系的构建

Establishment of pharmacological evaluation system on the character and taste in Fructus Evodiae

关键词:  吴茱萸  性味药理学  聚类分析  统计学

Key words:  Evodia  taste pharmacology  cluster analysis  statistics

摘要:

[目的] 以吴茱萸为研究对象,构建沟通中药性味理论与现代医药理论的性味药理学评价体系。[方法] 通过本草考证和现代文献研究,分别利用传统的中医思维方式、归纳演绎方法,并在建立现代药理指标文献数据库的基础上借助Logistic回归分析、聚类分析等现代统计学方法,建立吴茱萸性味-功效-药理指标的相关性,进而客观构建吴茱萸性味药理学评价体系。[结果] 基于古籍文献分析吴茱萸性味与药理指标关系为:辛味与镇痛、抗炎有相关性;苦味与止呕、止泻及抗胃溃疡有相关性。基于文献数据库分析中药“五味”与药理指标关系为:镇痛、抗炎与辛味相关,止呕、止泻及抗胃溃疡与苦味相关;聚类分析结果亦表明镇痛、抗炎是一类,止呕、止泻及抗胃溃疡为一类。 [结论] 本草考证和现代文献研究结果一致,均为辛味与镇痛、抗炎有相关性;苦味与止呕、止泻及抗胃溃疡有相关性,从而科学构建吴茱萸性味药理学评价体系。

Abstract:

[Objective] To construct the taste pharmacology evaluation system with communication of Chinese herb medicine theory and modern medical theory by taking Evodia as research object. [Methods] Through textual research and modern literature study, using the traditional Chinese way of thinking and deductive method, and based on the establishment of modern pharmacological targets literature database, using logistic by means of regression analysis and cluster analysis in the methods of modern statistics the Evodia taste-efficacy-pharmacological index correlation was established, and the Evodiae taste pharmacology evaluation system was then constructed objectively. [Results] Through analysis based on the literature, the index of Evodia taste and pharmacology were: pungent taste was associated with analgesic and anti-inflammatory effect, bitterness taste was associated with effect of preventing or arresting vomiting, stopping diarrhea and anti gastric ulcer. Analysis based on literature database, the relationship of traditional Chinese medicine “five flavor” and pharmacological index was: analgesic and anti-inflammatory were associated with pungent taste; preventing or arresting vomiting, stopping diarrhea and anti gastric ulcer were associated with bitterness taste. The results of cluster analysis also showed that the analgesic and anti-inflammatory were classified in one category, preventing or arresting vomiting, stopping diarrhea and anti gastric ulcer were in one category. [Conclusion] The results of herbal medicine research and modern literature research are the same, all of them is pungent taste and is associated with analgesic and anti-inflammatory, bitterness taste is associated with preventing or arresting vomiting, stopping diarrhea and anti gastric ulcer. The Evodia rutaecarpa taste pharmacology evaluation system was thereby built scientifically.