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| 地榆四黄散的提取工艺优化及凝胶剂的制备 |
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王颖1,2, 刘志东1,2, 曹晴1,2, 李琳1,2
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1.天津中医药大学, 天津市现代中药重点实验室-省部共建国家重点实验室培育基地, 天津 300193;2.天津中医药大学现代中药发现与制剂技术教育部工程研究中心, 天津 300193
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| 摘要: |
| [目的] 优选地榆四黄散的提取工艺,并制备凝胶剂。[方法] 采用正交实验法,以没食子酸、黄芩苷、黄芩素和大黄类相关成分的提取含量为指标,进行方差分析,筛选最优提取工艺,并制备凝胶剂。[结果] 四黄最佳提取工艺为用10倍量的50%乙醇热回流提取3次,每次1.5 h;地榆为用8倍量的水,回流提取3次,每次提取1.5 h.用1.5%的卡波姆及中药提取液制备凝胶剂的工艺可行。 [结论] 该凝胶剂制备工艺简便,质地细腻均匀。 |
| 关键词: 地榆四黄散 提取工艺 凝胶剂 |
| DOI：10.11656/j.issn.1672-1519.2012.01.26 |
| 分类号: |
| 基金项目:中国博士后科学基金特别资助项目(2010003304). |
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| Optimization of extracting art of Diyu SiHuang power and preparation of gel |
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WANG Ying1,2, LIU Zhi-dong1,2, CAO Qing1,2, LI Lin1,2
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1.Tianjin State Key Laboratory of Modern Chinese Medicine, Ministry of Education;2.Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin 300193, China
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| Abstract: |
| [Objective] To optimize the extracting art for Diyu Sihuang powder and prepare a gel. [Methods] Using orthogonal design method and taking extracted amount of gallic acid, baicali, baicalein and some related components of Rhubarb as the observing indexes, the extracting art was optimized by analysis of variance. Gel from the extract was developed. [Results] The optimum extracting conditions of Sihuang were obtained by adding ten times amount of 50% alcohol and extracted under reflux for 1.5 h, 3 times; while Diyu was obtained by adding eight times amount of water and extracted under reflux for 1.5 h, 3 times. The gel was prepared by using 1.5% Carbopol and the extraction was feasible. [Conclusion] The preparation technology of gel is simple, the produced gel was fine and uniform. |
| Key words: Diyu Sihuang power extract technology gel |
