| 摘要: |
| [目的]研究卡波姆981的流变学性质,为其在制剂中的应用提供参考。[方法]用Brookfield DV-ⅢULTRA流变仪测定不同条件下卡波姆溶液的黏度。通过与卡波姆934相比,对卡波姆981的流变学性质进行深入的探讨。[结果]卡波姆981溶液属于假塑性流体。卡波姆981对pH值、离子、机械剪切较敏感,对温度不敏感。[结论]卡波姆981对温度、离子、机械剪切的耐受性比卡波姆934要好。在制剂应用时,可以参考各条件下的流变学性质选择合适的条件。 |
| 关键词: 卡波姆981 黏度 流变学性质 |
| DOI：10.11656/j.issn.1672-1519.2012.02.23 |
| 分类号: |
| 基金项目:天津市高校“双五”科技计划项目(SW20080007) |
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| Rheological characteristics of Carbopol 981 |
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SUN Shi-zhen, WANG Ya-jing, ZHANG De-qin, TIAN Hui, WANG Yan-ming, PENG Shu-juan
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Tianjin University of TCM, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China
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| Abstract: |
| [Objective] To research the rheological characteristcs of Carbopol 981 for providing a conference in its preparation.[Methods] The viscosity of carbopol were measured under different conditions by Brookfield DV-Ⅲ ULTRA Rheometer.Through contrasting with Carbopol 934,the rheological characteristics of Carbopol 981 was deeply explored.[Results] Carbopol 981 was proved to be a false plastic fluid.It was more sensitive to pH change,ion concentration and mechanic shearing.[Conclusion] Carbopol 981 has better tolerance to temperature,ion concentration and mechanic shearing than Carbopol 934.These rheological data would be referred to choose suitable condition in the pharmaceutical preparation. |
| Key words: Carbopol 981 viscosity rheological characteristics |
