围手术期静滴血必净对老年人腹部手术后TNF-α、IL-6、IL-8的影响

Effect of Xuebijing injection in perioperative period on TNF-α, IL-6 and IL-8 in elderly patients after abdominal surgery

关键词:  血必净  腹部手术  细胞因子

Key words:  Xuebijing  abdominal surgery  cytokines

摘要:

[目的]通过研究围手术期静脉滴注血必净对老年人腹部手术后肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-8(IL-8)的影响,探讨血必净对老年人腹部手术患者的影响。[方法]将全麻下腹部手术的老年患者随机分为治疗组和对照组,治疗组于麻醉诱导前将血必净针100 mL加入100 mL生理盐水中,在30~40 min内静滴完毕,直至术后第5天。分别于术前1天,术后第1、3、7天采集静脉血标本,测定血浆中IL-6、IL-8、TNF-α的浓度。[结果]与对照组相比,治疗组应用血必净后的TNF-α、IL-6、IL-8均明显降低(P<0.01)。[结论]围手术期静滴血必净注射液对老年人腹部手术患者有益,可以有效降低患者的炎症反应,降低全身炎症反应综合征的严重程度。

Abstract:

[Objective] Through studying the effect of intravenous injection of Xuebijing in perioperative period of elderly patients after abdominal surgery on TNF-α,IL-6,IL-8 to explore whether Xuebijing is beneficial for these patients or not.[Methods] The elderly patients underwent abdominal surgery under general anesthesia were divided into treatment group and control group.The 100 mL Xuebijing in 100 mL normal saline were intravenously instilled into patients in the treatment group in 30~40 minutes before anesthesia induction, lasting for 5 days after operation.The venous blood samples were collected in one day before surgery,1,3 and 7 day after operation respectively for detecting the plasma concentration of IL-6,IL-8 and TNF-α.[Results] Compared with control group,the levels of TNF-α,IL-6,and IL-8 were significantly decreased in Xuebijing group(P<0.01).[Conclusion] The perioperative Xuebijing injection has beneficial effect on the elderly patients with abdominal surgery by inhibiting the inflammatory action and reducing the severity of SIRS.