| 摘要: |
| [目的] 观察参芪扶正注射液对癌症恶病质小鼠恶病质状态的影响,探讨参芪扶正注射液治疗癌症恶病质的作用机制。[方法] 建立C57小鼠癌症恶病质模型,观察参芪扶正注射液对恶病质小鼠的一般状况,如体质量、摄食量、饮水量的影响;观察血清中甘油三酯(TG)和胆固醇(CHOL)的水平变化。[结果] 参芪扶正注射液能明显增加癌症恶病质小鼠摄食量及饮水量,抑制体质量下降(P<0.05);可显著抑制血清中TG和CHOL的异常升高。[结论] 参芪扶正注射液对小鼠的癌症恶病质有明显的改善作用,其作用机制可能与其抑制脂肪分解有关。 |
| 关键词: 参芪扶正注射液 癌症恶病质 甘油三酯 胆固醇 |
| DOI：10.11656/j.issn.1672-1519.2012.03.26 |
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| Influence of Shenqi Fuzheng injection on blood lipids in mice with cancer cachexia |
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HUANG Li-sou1, WANG Zhen2
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1.Respiratory Department, The Third Affiliated Hospital of Zhejiang University of TCM, Hangzhou 310005, China;2.Respiratory Department, TCM Hospital of Zhejiang Province, Hangzhou 310006, China
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| Abstract: |
| [Objective] To observe the effect of Shenqi Fuzheng injection in mice with cancer cachexia and study its mechanism. [Methods] The model of cancer caxhexia was established in C57 mice and the changes of physiological conditions (body weight, food and water intake) and the levels of triglyceride (TG) and cholesterol (CHOL) were observed. [Results] Shenqi Fuzheng injection could significantly increase water and food intake of mice with cancer cachexia and inhibit the loss of body weight(P<0.05) and the abnormal increasing of TG and CHOL. [Conclusion] Shenqi Fuzheng injection can significantly improve the cancer caxhexia in cancer mice, and its mechanism may be related to the inhibition of lipolysis. |
| Key words: Shenqi Fuzheng injection cancer cachexia triglyceride cholesterol |
