| 摘要: |
| [目的] 研究柴胡、黄芩配伍抗肝纤维化的作用。[方法] 采用饲喂高脂饲料,饮用10%乙醇及皮下注射四氯化碳(CCL4)的复合因素法建立大鼠肝纤维化模型,应用柴胡、黄芩及配伍进行干预,酶联免疫吸附法(ELISA法)检测大鼠血清中透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、层黏蛋白(LN)、Ⅳ型胶原(Ⅳ-C)的变化,探讨柴胡、黄芩及柴胡、黄芩2:1配伍对肝纤维化大鼠的影响。[结果] 柴胡-黄芩2:1配伍能降低综合因素所致肝纤维化血清中HA、PCⅢ和Ⅳ-C的浓度(P<0.05).[结论] 柴胡、黄芩及配伍具有一定抗肝纤维化作用。 |
| 关键词: 柴胡 黄芩 配伍 肝纤维化 |
| DOI：10.11656/j.issn.1672-1519.2012.06.19 |
| 分类号: |
| 基金项目:陕西省中医药管理局项目(zy06);陕西省教育厅项目(12JK1016). |
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| Effect of Bupleurum, Scutellaria and its compatibility on hepatic fibrosis in rats |
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LI Min, WANG Bin, HOU Jian-ping, YANG Yan
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College of pharmacy, Shanxi College of TCM, Xianyang 712046, China
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| Abstract: |
| [Objective] To study the effect of Bupleurum, Scutellaria and its compatibility on hepatic fibrosis in rats. [Methods] Using the method of feeding fat diet, drinking 10% alcohol and subcutaneous injecting CCL4 to lead to liver fibrosis in rat and applying Bupleurum, Scutellaria and its compatibility to treat 7 days later. The serum concentration of hyaluronic acid (HA), Ⅲ procollagen (PC Ⅲ), laminin (LN) and type IV collagen (IV-C) was detected with ELISA. [Results] Bupleurum, Scutellaria and its compatibility could decrease the concentrations of HA, PC Ⅲ and IV-C in rats with hepatic fibrosis and the effect was significant in Bupleurum and Scutellaria compatibility(2:1) group. [Conclusion] Bupleurum,Scutellaria and its compatibility has some certain effect against hepatic fibrosis in rats. |
| Key words: Bupleurum Skullcap compatibility hepatic fibrosis |
