人参附子不同比例配伍对小鼠急性毒性的影响

Influence of Radix Ginseng and Radix Aconiti Lateralis Preparata in different proportion compatibility on acute toxicity in mice

关键词:  附子  人参  配伍减毒  急性毒性

Key words:  Radix Aconiti Lateralis Preparata  Radix Ginseng  attenuation with different compatibility  acute toxicity

摘要:

[目的] 考察人参附子不同比例配伍对小鼠急性毒性的影响,旨在从毒性角度考察人参附子配伍是否减毒。[方法] 运用均匀设计和固定附子剂量与人参不同配比两种方法考察人参附子不同比例配伍对小鼠急性毒性的影响。[结果] 均匀设计实验的研究结果表明,随着附子给药剂量的增多,小鼠的死亡率呈上升趋势,且随着人参对附子的比例增大减毒作用呈现增大趋势。固定附子LD₅₀与人参不同配比的减毒作用研究结果表明,人参与附子配伍的减毒作用在一定范围内随着人参剂量的增加而增加,尤其在人参:附子为1:1及大于1:1时更明显。[结论] 人参附子配比1:1为人参附子配伍减毒作用的分界点,可作为临床用药的参考依据。

Abstract:

[Objective] To investigation the effect of different compatibility of Radix Ginseng and Radix Aconiti Lateralis Preparata on toxicity in mice. [Methods] In this study two methods using uniform design and fixed dose of Radix Aconiti praeparata compatibility with Radix Ginseng were used to observe the influence of different proportion in compatibility of Radix Ginseng and Radix Aconiti Lateralis Preparata on acute toxicity in mice. [Results] The study of uniform design showed that mice mortality was increased with the dose increasing of Radix Aconiti Lateralis Preparata and with the proportion of Radix Ginseng increased the toxicitiy-decreasing effect had a increasing tendency. The research of the toxicity-attenuated role with the fixed LD₅₀ dose of Radix Aconiti Praeparata and different proportion of Radix Ginseng showed that toxicity- decreasing effect in this compatibility of Radix Ginseng and Radix Aconiti Praeparata increased with the increasing dose of Radix Ginseng in a certain range, especially the dose of Radix Ginseng was more than or equal to the dose of Radix Aconiti Lateralis Preparata. [Conclusion] The cutoff point of the effect of attenuation was at a compatibility between Radix Ginseng and Radix Aconiti Lateralis Preparata in 1:1, which can provide some references in he usage of drugs in the clinical practice.