扶正益气中药对阻塞性黄疸患者外周血清炎症介质和Th1/Th2的影响

Effects of strengthening and invigorating genuine Qi on peripheral serum inflammatory mediators and Th1/Th2 in patients with obstructive jaundice

关键词:  阻塞性黄疸  扶正益气  炎症介质  免疫功能

Key words:  obstructive jaundice  strengthening and invigorating genuine Qi  inflammatory mediator  immunologic function

摘要:

[目的] 观察阻塞性黄疸患者术后外周血清炎症介质和辅助性T细胞1(Th1)/辅助性T细胞2(Th2)的变化情况,探讨扶正益气中药的治疗作用机制.[方法] 将手术后的120例阻塞性黄疸患者随机分为治疗组60例、对照组60例,对照组行阻塞性黄疸术后常规治疗,治疗组在常规治疗的基础上辅以口服扶正益气中药,从术后第1天开始,连 服7d;观察两组患者术后7d外周血清炎症介质和Th1/Th2变化情况.[结果] 两组患者治疗后与治疗前比较,内毒素(ET)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)以及IL-4水平降低,IL-10水平增高,经统计学处理差异有统计学意义(P<0.05),但治疗组同对照组比较,其治疗后的变化更为明显,经统计学处理差异有统计学意义(P<0.05);酌-干扰素(IFN-酌)水平升高,但其差异无统计学意义(P>0.05);两组患者治疗后Th1/Th2比值明显增高,经统计学处理差异有统计学(P<0.05),治疗组与对照组比较,其变化趋势更为明显,经统计学处理差异有统计学意义(P<0.05).[结论] 扶正益气中药可降低阻塞性黄疸患者术后外周血浆ET及血清TNF-α、IL-6水平,提高IL-10水平,并可调节Th1/Th2比值的变化,从而发挥促进肝功能恢复的作用.

Abstract:

[Objective] To observe the influence of Chinese herbs with effect of strengthening and invigorating genuine Qi on peripheral serum inflammatory mediators and Th1/Th2 in patients with obstructive jaundice.[Methods] The 120 post-operative patients with ob-structive jaundice were randomly divided into treatment group of 60 cases and control group of 60 cases.The control group received con-ventional treatment after surgery against obstructive jaundice;in the treatment group the Chinese herbs with effect of strengthening andi nvigorating genuine Qi were supplemented on the basis of routine treatment from the first day after surgery for continuous seven days.The peripheral serum inflammatory mediators and Th1/Th2 were observed 7 d later.[Results] Compared with that before treatment the blood levels of ET,TNF-α,IL-6 and IL-4 after treatment were significantly lower(P<0.05).The levels of IL-10,Th1/Th2 were higher than those before treatment(P<0.05).But all the parameters in herbal medicine treated group were more obvious(P<0.05).The levels of IFN-after treatment were significantly higher than those before treatment(P>0.05).[Conclusion] Chinese herbs of strengthening and invigorating genuine Qi can effectively reduce the serum concentration of ET,TNF-α,IL-6,increase levels of IL-10,adjust the ratio of Th1/Th2 and so play a protective role in liver function.