| 摘要: |
| [目的] 观察知母水、醇提取液的急性毒性反应。[方法] 选择昆明种小鼠为受试对象，采用急性经口毒性实验测定知母水、醇提取液的的最大耐受量。[结果] 知母水提液的小鼠经口最大耐受量为35.0g/kg。知母80%乙醇提取液的小鼠经口最大耐受量为37.5g/kg。[结论] 知母水、醇提取液的毒性较低，临床给药安全可靠。 |
| 关键词: 知母|急性毒性|最大耐受量 |
| DOI：10.11656/j.issn.1672-1519.2014.06.13 |
| 分类号: |
| 基金项目:河北省中医药管理局资助项目（2012015）。 |
|
| Study on acute toxicity of water and alcohol extract of Anemarrhenae Rhizoma |
|
LIU Fang1, LI Lan-fang2, LIU Guang-jie1, JIANG Hong2, ZHANG Qin-zeng2
|
|
1.Department of Second Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China;2.Chinese Center for Disease Control and Prevention in Hebei Province, Shijiazhuang 050021, China
|
| Abstract: |
| [Objective] To observe the acute toxicity of water and alcohol extract of Anemarrhenae Rhizoma. [Methods] Kunming mice were used to test the maximum tolerated dose of water and alcohol extract of Anemarrhenae Rhizoma. [Results] The maximum tolerated dose of water extract of Anemarrhenae Rhizoma was 35.0 g/kg and the maximum tolerated dose of 80%alcohol extract of Anemarrhenae Rhizoma was 37.5 g/kg. [Conclusion] The water and alcohol extract of Anemarrhenae Rhizoma is safe for clinical administration. |
| Key words: Anemarrhenae Rhizoma|acute toxity|maximum tolerated dose |
