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| 慢性神经根型颈椎病动物模型的建立 |
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金哲峰1, 徐凡平2, 朱立国3, 于杰3, 王平1, 毕方杉4
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1.天津中医药大学第一附属医院, 天津 300193;2.北京中医医院, 北京 100010;3.中国中医科学院望京医院, 北京 100102;4.北京市丰盛中医骨伤专科医院, 北京 100033
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| 摘要: |
| [目的] 通过模拟慢性颈椎间盘退变及关节突关节双重退变,建立慢性神经根型颈椎病的动物模型。[方法] 将48只SD大鼠分层随机分为两组:模型组、假手术组。观察大鼠行为学变化,并分别于术前1 d、术后29 d拍颈椎X线片侧位片,观察椎间盘退变的情况;术前1 h、术后29 d后分别测定右侧臂丛神经的感觉神经传导速度和运动神经传导速度;记录神经电生理变化。[结果] 该模型可以出现明显椎间盘变化及神经功能传导损伤的变化。[结论] 模拟慢性颈椎间盘退变及关节突关节双重退变的动物模型可以对神经根型颈椎病(慢性期)加以反映。 |
| 关键词: 神经根型颈椎病 慢性期 动物模型 |
| DOI：10.11656/j.issn.1672-1519.2015.09.13 |
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| Establishment of chronic animal model of the nerve root cervical spondylosis |
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JIN Zhe-feng1, XU Fan-ping2, ZHU Li-guo3, YU Jie3, WANG Ping1, BI Fang-shan4
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1.The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2.Beijing Hospital of Traditional Chinese Medicine, Beijing 100010, China;3.Wangjing Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100102, China;4.Beijing Fengsheng Special Hospital of Traditional Medical Traumatology and Orthopaedics, Beijing 100033, China
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| Abstract: |
| [Objective] To establish chronic stage model of the nerve root cervical spondylosis in the rat through simulation of chronic cervical intervertebral disc and zygapophyseal joints degeneration. [Methods] The 48 SD rats were randomly divided into two groups, model group and false operation group, and observation of intervertebral disc degeneration by cervical spine lateral X-ray respectively 1 d of preoperative and 29 d of postoperative, and detecting the right brachial plexus nerve sensory nerve and motor nerve conduction velocity, recording electrophysiological changes. [Results] The model could obviously change of intervertebral disc and nerve conduction function damage changes. [Conclusion] The method of simulation of chronic cervical intervertebral disc and zygapophyseal joints degeneration could reflect a chronic stage model of the nerve root cervical spondylosis. |
| Key words: nerve root cervical spondylosis chronic stage animal model |
