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| 针刺对痴呆小鼠大脑神经元超微结构的影响 |
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郭睿婧1, 付于2, 董树旭3, 刘宇婧4, 赵轼轩3, 郝婷婷4, 茹永新3, 张思彬4, 颜妙璇4
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1.天津市环湖医院, 天津 300060;2.天津中医药大学第一附属医院, 天津 300193;3.中国医学科学院血液病医院电镜室, 天津 300020;4.天津中医药大学研究生院, 天津 300193
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| 摘要: |
| [目的] 研究三焦针法对痴呆小鼠皮质和海马CA1区神经元线粒体结构的影响。[方法] 选取雄性SAMP8小鼠30只(随机分成模型组、非穴组、穴位组)和10只SAMR1小鼠(正常对照组)。持续治疗30日后,采用电子显微镜对小鼠大脑皮质顶叶和海马CA1区进行观察。[结果] R1组皮质顶叶和海马CA1区超微结构正常;SAMP8模型组小鼠神经元部分线粒体肿大、部分变性、部分脂肪化和坏死;SAMP8三焦针刺组线粒体肿大减少,少数线粒体变性,脂肪化和坏死;非经穴针刺组线粒体少数介于两者之间。[结论] 三焦针法能有效改善SAMP8小鼠大脑皮质和海马CA1区神经原线粒体病理性损伤。 |
| 关键词: 三焦 针灸 超微结构 阿尔茨海默病 |
| DOI：10.11656/j.issn.1672-1519.2015.12.09 |
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| 基金项目:国家自然科学基金项目(81173414)。 |
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| Effects on the acupuncture method on the ultrastructure of the cerebrum of 8-month-old swift aging mice |
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GUO Rui-jing1, FU Yu2, DONG Shu-xu3, LIU Yu-jing4, ZHAO Shi-xuan3, HAO Ting-ting4, RU Yong-xin3, ZHANG Si-bin4, YAN Miao-xuan4
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1.Tianjin Huanhu Hospital, Tianjin 300060, China;2.The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;3.Laboratory of Electron Microscopy, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences, Tianjin 300020, China;4.Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
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| Abstract: |
| [Objective] To investigate the influence of acupuncture method of triple energizer on ultrastructure of the cortex and hippocampus CA1 region of 8-month-old swift aging mice (SAMP8). [Methods] The dementia mice were randomly divided into 3 groups: model group, acupuncture group and non-acupoint acupuncture group, and a normal group(SAMR1) group were set up. The mouse cerebral cortex and hippocampus CA1 region were observed by electron microscopy. [Results] Ultrastructure of the cortex and hippocampus CA1 region of the SAMR1 mice were almost normal. Acupuncture group had better expression on ultrastructure of the cortex and hippocampus CA1 region of SAMP8 mice than that in other two groups. [Conclusion] The acupuncture method of triple energizer has protective effects on ultrastructure of the cortex and hippocampus CA1 region of SAMP8 mice. |
| Key words: Sanjiao acupuncture electron microscopy alzheimer's disease |
