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| 糖痹康治疗糖尿病周围神经病变的临床研究 |
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吕翠岩1,2, 张胜容1, 赵文景1, 张竹华3, 蔡朕1, 郑桂敏1, 孟元1, 赵静1, 王晖1, 陈洋子1, 刘铜华2
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1.首都医科大学附属北京中医医院肾内科, 北京 100010;2.北京中医药大学, 北京 100029;3.首都医科大学附属北京中医医院心血管科, 北京 100010
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| 摘要: |
| [目的] 采用自身前后对照方法,评价中药复方糖痹康治疗糖尿病周围神经病变(DPN)的临床有效性及安全性。[方法] 在基础治疗(如血糖、血压、血脂等)的基础上,给予35例DPN患者口服糖痹康配方颗粒,治疗8周后,对患者的各项指标(如:中医证候、实验室检查及肌电图)进行客观评价。[结果] 糖痹康治疗前后受试对象的双侧胫运动神经(MCV)、感觉神经(SCV)传导速度明显改善(P<0.05),且治疗前后安全性指标(血糖、糖化血红蛋白、血脂及血压)均在正常范围内,无显著性差异(P>0.05)同时未出现药物不良反应。[结论] 中药复方糖痹康可显著改善DPN患者的临床症状、提高神经传导速度、显著降低国际公认糖尿病周围神经病变积分并且总有效率达到91.14%。 |
| 关键词: 糖痹康 糖尿病周围神经病变 临床研究 自身对照 中医 |
| DOI：10.11656/j.issn.1672-1519.2016.01.02 |
| 分类号: |
| 基金项目:国家重大新药创制项目(2012ZX09102201-001);教育部博士点基金立项课题项目(20110013130001);北京中医药大学创新团队项目(2011-CXTD-19);教育部中医养生学重点实验室资助项目;北京市中医养生学重点实验室资助项目。 |
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| Clinical research on diabetic peripheral neuropathy treated by Tangbikang |
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LV Cui-yan1,2, ZHANG Sheng-rong1, ZHAO Wen-jing1, ZHANG Zhu-hua3, CAI Zhen1, ZHENG Gui-min1, MENG Yuan1, ZHAO Jing1, WANG Hui1, CHEN Yang-zi1, LIU Tong-hua2
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1.Department of Nephrology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China;2.Beijing University of Chinese Medicine, Beijing 100029, China;3.Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China
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| Abstract: |
| [Objective] To objective evaluate of clinical efficacy and safety of treatment of diabetic peripheral neuropathy(DPN) by Chinese herbal compound Tangbikang, the clinical trials were adopted by self-control. [Methods] The 35 DPN patients conforming to the diagnostic criteria, based on the basic treatment for blood pressure, blood glucose and blood lipid, were given Chinese herbal compound Tangbikang. After curing for 8 weeks, we measured some indicators, like traditional Chinese medicine (TCM) syndrome, laboratory examination and electromyography. [Results] After the treatment by Tangbikang, the conduction velocities of MCV and SCV was better than before, and the difference was significant (P<0.05). Security Index including blood glucose, glycosylated hemoglobin, blood lipid and blood pressure with normal limits, the difference was insignificant (P>0.05), and there were no obvious side effects whreh had been found during the treatment. [Conclusion] Chinese herbal compound Tangbikang could improve of symptom, the nerve conductive velocity and the diabetic peripheral neuropathy integralsobviously, and the total effective rate of the Tangbikang was 91.14%. |
| Key words: Tangbikang diabetic neuropathy clinical research self-control traditional Chinese medicine |
