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| 多指标正交设计优选芪防鼻敏颗粒水提醇沉工艺 |
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薛丹1, 倪健1, 张鹏1, 杨春静1, 赵阳1, 夏振文1, 尹兴斌1, 李友林2
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1.北京中医药大学中药学院, 北京 100102;2.中日友好医院国家中医药管理局重点研究室, 北京 100029
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| 摘要: |
| [目的] 多指标综合优选芪防鼻敏颗粒的水提醇沉工艺。[方法] 以黄芪甲苷、芍药苷提取率为指标,考察提取工艺条件;以黄芪甲苷、芍药苷转移率为指标,考察醇沉条件。[结果] 最佳水提醇沉工艺为饮片加12倍加水量,提取3次,每次1.5 h;浓缩液相对密度为1.15~1.20(60℃)时,加乙醇为60%。[结论] 该工艺稳定可行,可为芪防鼻敏颗粒的工业生产提供科学依据。 |
| 关键词: 黄芪甲苷 芍药苷 水提醇沉 多指标 |
| DOI：10.11656/j.issn.1672-1519.2016.01.10 |
| 分类号: |
| 基金项目:国家自然科学基金面上项目(81173563);北京市科学技术委员会"十病十药"研发项目(Z141100002214018)。 |
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| Optimization of aqueous extraction-alcohol precipitation technology for Qifang Bimin granules with multi-index orthogonally designed experiments |
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XUE Dan1, NI Jian1, ZHANG Peng1, YANG Chun-jing1, ZHAO Yang1, XIA Zhen-wen1, YIN Xing-bin1, LI You-lin2
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1.College of Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China;2.China-Japan Friendship Hospital and Key Laboratory of the State Pharmaceutical Administration, Beijing 100029, China
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| Abstract: |
| [Objective] To investigate the technology of optimal water extraction and alcohol precipitation for Qifang Bimin granules with Multi-index. [Methods] The study employed the extraction rate of astragaloside IV and paeoniflorin as evaluation indexes to investigate extraction conditions. We also investigate alcohol precipitation condition in the metastatic rate of astragaloside IV and paeoniflorin as detective index. [Results] The optimal water extraction and alcohol precipitation was extracted 3 times, with 12 folds the amount of water, 1.5 h for each time. The extracts were concentrated to the relative density of 1.15~1.20 (60℃) with the concentration of alcohol precipitation 60%. [Conclusion] Optimized water extraction and alcohol precipitation technology was reasonable and feasible and it could provide a reference for industrial production of Qifang Bimin granules. |
| Key words: astragaloside IV paeoniflorin water extraction and alcohol precipitation multi-index |
