补阳还五汤对奥沙利铂致神经病理痛模型大鼠的干预作用

Intervention effects of Buyang Huanwu decoction on neuropathic pain oxaliplatin induced in the rat model

关键词:  补阳还五汤  神经病理痛  奥沙利铂  热痛阈值

Key words:  Buyang Huanwu decoction  oxaliplatin  neuropathic pain  thermal pain threshold

摘要:

[目的] 研究通过建立奥沙利铂致大鼠慢性神经病理痛模型,选择补阳还五汤为代表方揭示其对奥沙利铂致神经病理痛的干预作用。[方法] 选取健康清洁级雄性成年大鼠60只,随机分为4组。空白对照组、奥沙利铂组、补阳还五汤对照组和补阳还五汤治疗组。检测4组大鼠热痛阈值并监测大鼠体质量变化。[结果] 第2周补阳还五汤治疗组热痛阈值与模型组相比差异有统计学意义。补阳还五汤可拮抗奥沙利铂化疗大鼠引起的热痛阈值和体质量的变化。[结论] 补阳还五汤治疗奥沙利铂所致神经病理痛符合中医学的基本理论,该方具有广阔的应用前景。

Abstract:

[Objective] The aim of the present study was to reveal the intervention of Buyang Huanwu decoction as a representative soup to oxaliplatin-induced neuropathic pain using oxaliplatin induced rat chronic neuropathic pain model. [Methods] Sixty healthy adult male and clean grade rats were randomly divided into four groups including Blank group, oxaliplatin group, Buyang Huanwu decoction control group and Buyang Huanwu decoction treatment group. Body weight measurements and the thermal pain threshold of rats were assessed in rats of the four groups. [Results] The thermal pain threshold of Buyang Huanwu decoction treatment group compared with that in model group was significantly different in second week. Buyang Huanwu decoction can antagonize change of thermal pain threshold and body weight in rats induced by oxaliplatin chemotherapy. [Conclusion] The present experimental study has confirmed Buyang Huanwu treated neuropathic pain oxaliplatin-induced is fully consistent with the basic theory of Chinese medicine. Buyang Huanwu decoction has broad application prospects.