温阳活血法治疗HBV相关性肝衰竭的临床疗效分析

Analysis on the clinical curative effect of Wenyang Huoxue activation therapy in treating HBV related liver failure

关键词:  HBV  肝衰竭  温阳活血  临床疗效

Key words:  HBV  liver failure  Wenyang Huoxue  clinical curative effect

摘要:

[目的] 分析温阳活血法治疗HBV相关性肝衰竭的临床疗效，进一步探讨其作用机制。[方法] 选取本院住院诊断为病毒性肝炎，乙型，慢性或慢加亚急性肝衰竭的患者，随机分成中西医结合组和西医组，中西医结合在西医组西医综合治疗的基础上加用以温阳活血法为主要治法的中药，观察患者的生化指标、临床症状积分及有效率的情况。[结果] 治疗后两组丙氨酸氨基转移酶（ALT）、门冬氨酸氨基转移酶（AST）、总胆汁酸（TBA）均较治疗前显着下降，白蛋白（ALB）、凝血酶原活动度（PTA）较治疗前升高。治疗后第4周和第8周，中西医结合组患者血清总胆红素（TBIL）水平低于西医组，组间比较，第8周差异有统计学意义（P<0.05）。治疗后患者症状积分较治疗前下降，第4周、第8周分别与治疗前比较，差异具有统计学意义（P<0.05）。治疗后两组有效率、无效率比较，差异具有统计学意义（P<0.05）。[结论] 温阳活血法是治疗HBV相关性肝衰竭有效、可行、可靠的方法之一。

Abstract:

[Objective] To analyze the clinical curative effect of Wenyang Huoxue activation therapy in treating HBV related liver failure, and to explore its further action mechanism. [Methods] Patients diagnosed as viral hepatitis, hepatitis B, slow and subacute or chronic liver failure were selected from our hospital, randomly divided into combine traditional Chinese and Western medicine group as well as Western medicine group, and the combine traditional Chinese and Western medicine group were treated on the basis of Western medicine comprehensive treatment combined Chinese medicine which used Wenyang Huoxue method as the main treatment, to observe the biochemical indicators and clinical symptoms of patients with integral and efficient. [Results] The ALT, AST and TBA were decreased significantly after treatment in the group. The ALB and PTA were higher than the levels before treatment. The 4 and 8 weeks after treatment, the patients' serum TBIL level of combine traditional Chinese and Western medicine group was lower than Western medicine group, and the comparison between the two groups showed that 8 weeks' difference was statistically significant(P<0.05). The symptoms points of patients were fall after treatment and the difference between two groups of 4 weeks and 8 weeks were statistically significant (P<0.05). Comparison of inefficient and efficient rate in two groups, the difference was statistically significant after treatment(P<0.05). [Conclusion] The therapy of Wenyang Huoxue is one of the effective, feasible and reliable methods in treating HBV liver failure.