中药治疗痛风相关专利用药规律分析

Discussion of traditional Chinese medicine regularity for gout

关键词:  中药  痛风  用药规律  专利文献分析

Key words:  traditional Chinese medicine  gout  medication regularity  patent literature analysis

摘要:

[目的] 分析中药治疗痛风的用药规律和特点，为中医治疗痛风提供参考和借鉴。[方法] 检索近10年相关专利，将符合标准的484篇中医治疗痛风专利中的中药归类，并分别查出其功效、性、味、归经、证型、治则，用Excel进行统计分析。[结果] 经过统计分析发现，治疗痛风出现频数最高为茯苓，其次是牛膝、当归，占全部用方的85.96%；从功效角度以利湿为主共达29.68%，其次是活血化瘀药、补虚药、清热药，此3类药物占全部功效组成的48.60%；药物归经以归肝经的药物为最多，其次是归肺经、胃经、脾经、肾经的药物，药物归经占到了全部用药归经的74.76%；从药味角度以甘味为最多，其次是辛味、苦味药，此3药味占到了全部用药药味的62.56%；从药性角度主要是性温，其次是性寒、性平的药物，此3种药性占到了全部用药药性的69.65%。从中医证型角度主要为：湿热蕴结证45.94%、瘀血阻滞证24.48%、肝肾亏虚证17.75%、脾虚湿盛证11.83%等四大主证。[结论] 从以上规律中可以看出常用药物临床上多选用清热利湿、活血化瘀、疏肝补肾、健脾化浊之法。

Abstract:

[Objective] To investigate the regularity and characteristics of prescriptions for treating gout order to provide the references for the traditional Chinese medicine (TCM) treatment of gout. [Methods] This article searched the related patent literatures in recent 10 years. The inclusion criteria and exclusion criteria of the 484 papers were classified and then their efficacy,property and flavor and meridian distributions were founded with Excel software for statistical analysis. [Results] The highest frequency drugs are poria cocos and achyranthes bidentata, angelica, accounting for more than 85.96% of all herbs. The main drugs were those for dampness-disinhibiting medicinal,accounting for 29.68%, followed by invigorating blood circulation and eliminating stasis, tonifying and antipyretics drug. These three kinds of drugs accounted for 48.60%. As for the meridian distribution, the liver meridian drugs were most commonly used, followed by the lung and stomach, spleen, kidney meridians drugs. The five meridians drugs accounted for 74.76%. In terms of the drug tastes, sweet taste was the most common, followed by the pungent and bitter drugs, all the three flavors accounting for 62.56%. From the drugs nature, warm drugs were the first, followed by cold and general natures drugs, all of them accounting for 69.65%. From the perspective of TCM syndrome types are mainly: damp and hot accumulate knot of syndrome accounting for 45.95%, blood stasis block accounting for 24.48%, liver and kidney deficiency syndrome accounting for 17.75%, excessive dampness due to deficiency in spleen accounting for 11.83% and so on. [Conclusion] From the regularity of drugs, we could conclude that the commonly tonifying spleen and kidney, removing dampness and invigorating blood circulation, eliminating stasis and clearing heat and soothing liver are the main treatments.