木香在胃肠安丸中药效作用靶点与颗粒剂等效性评价

Study on radix aucklandiae pharmacodynamic targets in Weichang'an pill and the equivalent evaluation of formula particles

关键词:  木香  配方颗粒  胃肠推进  镇痛  等效性评价

Key words:  radix aucklandiae  formula particles  intestinal propellant movement  analgesia  equivalent evaluation

摘要:

[目的]通过对胃肠安丸中君药木香的主成分分析及药理作用机制研究，阐释胃肠安丸理气止痛、芳香化浊药效物质基础；对比木香配方颗粒与饮片药效学差异，客观评价配方颗粒与水煎剂药效等效性。[方法]采用红外光谱法（IR）、高效液相色谱法（HPLC）检测木香全组分及主成分含量，通过胃排空和小肠推进、热板及醋酸扭体实验探讨木香药效作用机制及颗粒剂等效性评价。[结果]木香可有效降低实验小鼠胃内残留率、提高小肠炭末推进率。配方颗粒剂与传统水煎剂间未见统计学差异。[结论]木香通过促进胃肠蠕动，调整胃肠动力以镇痛。配方颗粒和水煎剂在成分种类和含量方面具有差异，但两者药效作用相近。

Abstract:

[Objective] This experiment selected radix aucklandiae as principal drug of Weichang'an pills. By analyzing principal component and pharmacological effects, it was probed pharmacodynamic material basis of Weichang'an pills and contrast radix aucklandiae formula particles and decoction pharmacodynamic differences, evaluate the equivalence objectively.[Methods] This experiment adopt infrared spectrometry(IR) and high performance liquid chromatography(HPLC) to analyze all the components and principal component content of radix aucklandiae. By gastric emptying and intestinal propellant movement, hot plate reaction and rotating body reaction probing the mechanism of regulation and equivalent evaluation of formula particles.[Results] Radix aucklandiae can reduce the of rategastric remnant, improve the rate of propeling carbon powder in small intestin. There was no significant difference between radix aucklandiae decoction and formula particles.[Conclusion] Radix aucklandiae can relieve pain by promoting gastrointestinal peristalsis and adjusting the gastrointestinal dynamia. Although formula particles and decoction have some differences in kinds and contents, but the effect is similar.